BioCentury | Nov 14, 2019
Targets & Mechanisms

New roles for HDACs in the cytoplasm and muscle disorders

...HDAC3 - Histone deacetylase 3 HspA8 (HSC70) - Heat shock 70 kDa protein 8 PGC-1α (PPARGC1A...
BioCentury | May 10, 2019
Translation in Brief

Tapping mutations for liver regeneration

Certain mutations in patients with chronic liver disease may be helpful rather than harmful, and could be tapped for regenerative medicine, according to a team from the Children’s Medical Center Research Institute at UT Southwestern....
BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...CCAAT enhancer binding protein α (CEBPA) 63 Peroxisome proliferation activated receptor γ coactivator 1-α (PGC-1α; PPARGC1A...
...BRCA2 PARP - Poly (ADP-ribose) polymerase PD-1 (PDCD1) (CD279) - Programmed cell death 1 PGC-1α (PPARGC1A...
BioCentury | Aug 10, 2018
Targets & Mechanisms

Getting to function

...Solute carrier family 2 facilitated glucose transporter member 4; MSTN (GDF8) - Myostatin; PGC-1α (PPARGC1A...
BioCentury | Dec 5, 2017
Distillery Therapeutics

Renal

...type III domain containing 5 (FNDC5; irisin); peroxisome proliferation activated receptor γ coactivator 1-α (PGC-1α; PPARGC1A...
...Medicine, Houston, Texas email: zhaoyonh@bcm.edu Hongjiang Li Baylor College of Medicine Fibronectin type III domain containing 5 (FNDC5) (irisin) Peroxisome proliferation activated receptor (PPAR) gamma coactivator 1-alpha (PGC-1alpha) (PPARGC1A)...
BioCentury | May 3, 2017
Distillery Therapeutics

Endocrine / Metabolic

...animal models of Type II diabetes. TARGET/MARKER/PATHWAY: Peroxisome proliferation activated receptor γ coactivator 1-α (PGC-1α; PPARGC1A...
...23, 2017 doi:10.1016/j.cell.2017.03.001 CONTACT: Pere Puigserver, Dana-Farber Cancer Institute, Boston, Mass. email: pere_puigserver@dfci.harvard.edu Karen Tkach Dana-Farber Cancer Institute Peroxisome proliferation activated receptor (PPAR) gamma coactivator 1-alpha (PGC-1alpha) (PPARGC1A) Diabetes...
BioCentury | Nov 1, 2016
Distillery Therapeutics

Cancer

...in other animal models of melanoma. TARGET/MARKER/PATHWAY: Peroxisome proliferation activated receptor γ coactivator 1-α (PGC-1α; PPARGC1A...
...Boston, Mass. email: pere_puigserver@dfci.harvard.edu Karen Tkach Harvard Medical School Peroxisome proliferation activated receptor (PPAR) gamma coactivator 1-alpha (PPARGC1A...
BioCentury | Oct 27, 2016
Targets & Mechanisms

T cell gas, tumor brake

...RAFT1) - Mammalian target of rapamycin NRF2 (NFE2L2) - Nuclear factor (erythroid-derived 2)-like 2 PGC-1α (PPARGC1A...
...Inhibitor of DNA binding 2; mTOR (FRAP; RAFT1) - Mammalian target of rapamycin; PGC-1α (PPARGC1A...
...factor (erythroid-derived 2)-like 2 (NFE2L2) (NRF2) Peroxisome proliferation activated receptor (PPAR) alpha Peroxisome proliferation activated receptor (PPAR) gamma Peroxisome proliferation activated receptor (PPAR) gamma coactivator 1-alpha (PGC-1alpha) (PPARGC1A) Transcription...
BioCentury | Aug 25, 2016
Distillery Therapeutics

Therapeutics: Peroxisome proliferation activated receptor γ coactivator 1-α (PPARGC1A; PGC-1a)

...Cancer INDICATION: Melanoma; viral infection Mouse studies suggest enhancing PPARGC1A activity in T cells could help...
...In a mouse model of melanoma, adoptive transfer of tumor-targeting T cells induced to express PPARGC1A...
...chronic lymphocytic choriomeningitis virus (LCMV) infection, adoptive transfer of virus-targeting T cells induced to express PPARGC1A...
BioCentury | Jun 30, 2016
Distillery Therapeutics

Therapeutics: Peroxisome proliferation activated receptor γ coactivator 1α (PPARGC1A; PGC-1α)

...studies suggest promoting PPARGC1A expression could help treat metastatic prostate cancer. In prostate cancer patients, PPARGC1A...
...compared with unmodified PPARGC1A expression. In a xenograft mouse model of metastatic prostate cancer, lentiviral-mediated PPARGC1A...
...include identifying compounds that promote PPARGC1A expression. TARGET/MARKER/PATHWAY: Peroxisome proliferation activated receptor γ coactivator 1α (PPARGC1A...
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