Liquidity is looming for the long list of investors who poured $1.9 billion into Grail, now that the early cancer detection company has filed for an IPO on NASDAQ. Grail Inc. hasn’t yet set terms...

Hesperos’ Human-on-a-Chip techIn an Advanced Therapeutics paper, a University of Central Florida team led by Hesperos Inc. co-founder and chief scientist James Hickman tested the efficacy of...

As the smoke clears from Jiankui He’s bombshell germline editing announcement, the gap between where the gene editing field is now and where it would need to be to support responsible germline editing has become...

New Therapeutic Targets and Biomarkers: June 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during June 2018. Therapeutic targets are defined as any protein, gene or other...

INDICATION: Small cell lung cancer Patient sample and cell culture studies suggest promoting IGFBP5 expression or inhibiting POU2F3 or IGF1R could help treat POU2F3-expressing small cell lung cancer (SCLC). In tumor samples from SCLC patients,...

In a Genes & Development paper , scientists at Cold Spring Harbor Laboratory identified a new subtype of small cell lung cancer defined by high levels of POU class 2 homeobox 3 (POU2F3; OCT11) and suggest...

TECHNOLOGY: Cell models A method of directly reprogramming human adult T cells into neurons could be used to generate cell-based models of neurological diseases. The method involves transfecting primary human T cells with a combination...

While last week’s Nature paper on gene editing of human embryos was a first in the U.K., it was more notable for the ground it broke than for its translational implications. Earlier studies from U.S....

New Therapeutic Targets and Biomarkers: July 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during July 2017. Therapeutic targets are defined as any protein, gene or other...

INDICATION: Brain cancer Cell culture and mouse studies suggest nanoparticles loaded with siRNAs targeting SOX2 , OLIG2 , SALL2 , and POU3F2 could help treat the proneural subtype of glioblastoma multiforme (GBM). In two proneural GBM cell lines,...