18:25 , Jun 13, 2018 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Cell models A method of directly reprogramming human adult T cells into neurons could be used to generate cell-based models of neurological diseases. The method involves transfecting primary human T cells with a combination...
21:34 , Aug 3, 2017 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: July 2017

New Therapeutic Targets and Biomarkers: July 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during July 2017. Therapeutic targets are defined as any protein, gene or other...
20:34 , Jul 25, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell culture and mouse studies suggest nanoparticles loaded with siRNAs targeting SOX2 , OLIG2 , SALL2 , and POU3F2 could help treat the proneural subtype of glioblastoma multiforme (GBM). In two proneural...
07:00 , May 26, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Baculovirus-based vector system for transient, simultaneous expression of multiple genes for genome editing or cellular reprogramming

Drug platforms TECHNOLOGY: Expression systems A baculoviral vector-based system for transient gene expression could be used to develop genome editing- or cellular reprogramming-based therapies. The vector system involved modifying baculovirus by inserting a plasmid containing...
07:00 , May 5, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Direct reprogramming of human adult fibroblasts into mature neurons for screening neuroprotectants and generating disease models

Disease models TECHNOLOGY: Cell models A method of directly reprogramming human adult fibroblasts into mature neurons could generate cells for screening neuroprotective compounds and developing models of neurological diseases. Fibroblasts derived from healthy volunteers were...
07:00 , Mar 17, 2016 |  BC Innovations  |  Translation in Brief

Trans-hemispheric express

A University of North Carolina at Chapel Hill team has made human neural progenitor cells directly from fibroblasts and shown the transdifferentiated cells can serve as tumor-homing carriers of chemotherapeutic agents for brain cancer. While...
07:00 , Aug 18, 2011 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Direct conversion of fibroblasts into functional neurons A method for directly converting human fibroblasts into functional neurons could be useful for...
08:00 , Feb 18, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Approach

Approach Summary Licensing status Publication and contact information Drug platforms Direct conversion of fibroblasts into functional neurons A cell culture study suggests that the direct conversion of mouse fibroblasts into functional neurons could be useful...
08:00 , Feb 18, 2010 |  BC Innovations  |  Tools & Techniques

Bypassing the iPS logjam

Researchers at the Stanford University School of Medicine have found a way to efficiently convert mouse fibroblasts into functional neurons without first reverting the skin cells to a pluripotent state. 1 The protocol could make...