BioCentury | May 7, 2019
Distillery Techniques

Expression of multigene panels in CNS cell types as markers of early AD

...genes included synaptosomal-associated protein 25 (SNAP25) in oligodendrocytes, RAR-related orphan receptor A (RORA) in microglia, potassium voltage-gated channel interacting protein 1 (KCNIP1)...
...C1q C chain (C1QC) Glial fibrillary acidic protein (GFAP) Leucine rich repeat and Ig domain containing 1 (LINGO1) Potassium voltage-gated channel interacting protein 1 (KCNIP1) RAR-related...
BioCentury | Mar 1, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: February 2018

New Therapeutic Targets and Biomarkers: February 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during February 2018. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Feb 28, 2018
Distillery Therapeutics

Neurology

INDICATION: Pain Cell culture and rat studies identified a KCNIP3-based inhibitor of TRPV1 that could help treat inflammatory pain. In a cell-based activity assay, an N-terminal fragment of KCNIP3 (residues 31-50) decreased cell surface localization...
BioCentury | May 3, 2017
Distillery Therapeutics

Neurology

...INDICATION: Pain Mouse studies suggest promoting co-expression of KCND3 , KCNIP1 and DPP-10 could help treat...
...root ganglia (DRG) from a spinal ligation mouse model of neuropathic pain, levels of KCND3, KCNIP1...
...plasmid. Next steps could include identifying compounds that promote KCND3, KCNIP1 and DPP-10 expression. TARGET/MARKER/PATHWAY: Potassium voltage-gated channel interacting protein 1 (KCNIP1)...
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