BC Innovations | Apr 25, 2017
Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Patient sample and cell culture studies suggest promoting KCNQ1 expression or inhibiting its negative regulator TCF4 could help treat colorectal cancer. In patients, low levels of KCNQ1 and high levels of TCF4...
BC Innovations | Nov 9, 2016
Distillery Therapeutics

Cardiovascular

INDICATION: Arrhythmia In vitro studies suggest a KCNQ1 agonist could help treat long QT syndrome (LQTS) caused by KCNQ1 mutations. In Xenopus oocytes expressing eight LQTS-associated KCNQ1 mutations, a previously reported KCNQ1 agonist decreased the...
BC Innovations | Apr 14, 2011
Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Cardiovascular disease Potassium channel Kv7.1 (KCNQ1) Patient studies suggest that KCNQ1 activity could help predict risk of cardiac events in long QT syndrome (LQTS)...
BC Innovations | Oct 29, 2009
Distillery Techniques

Technology: Disease models

Approach Summary Licensing status Publication and contact information Disease models Mouse model of sudden unexplained death in epilepsy (SUDEP) Mice expressing a mutant potassium channel Kv7.1 (Kcnq1) could help identify therapies to prevent SUDEP. In...
BC Innovations | Sep 24, 2009
Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Thyroid disease Potassium voltage-gated channel, Isk-related family, member 2 (KCNE2); Potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) Studies in mice suggest that enhancing...
BC Innovations | Jan 8, 2009
Cover Story

Taking the inflammation out of epilepsy

Italian and U.S. researchers have proposed treating epileptic seizures by targeting an inflammatory pathway outside the blood-brain barrier: leukocyte migration and recruitment. 1 The strategy potentially could help patients whose seizures are not adequately controlled...
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