07:00 , Jul 24, 2014 |  BC Innovations  |  Cover Story

It is an RNA world

RNA-based molecules have redefined the universe of tractable targets by putting virtually anything that is gene encoded within reach of a disease-modifying agent. This redefinition has launched RNA as the biotech industry's third drug modality....
07:00 , Jul 25, 2013 |  BC Innovations  |  Targets & Mechanisms

Silencing neuropathic pain

The seemingly intractable nature of neuropathic pain has led drug developers to look beyond classical receptor and transporter protein targets and explore the emerging field of epigenetics to find new options. Now, researchers at The...
07:00 , Jul 25, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Potassium channel Kv1.2 (KCNA2) Rat studies suggest targeting KCNA2 antisense long noncoding RNA (lncRNA) could help treat neuropathic pain. In a rat model for...
07:00 , May 31, 2012 |  BC Innovations  |  Cover Story

Channel-tuning neuropathy

An international team has shown that a peptide inhibitor of methylglyoxal treated hypersensitivity to pain in diabetic mice. 1 Although future studies could determine whether the mechanism plays a role in other types of neuropathic...
07:00 , Jul 31, 2008 |  BC Innovations  |  Targets & Mechanisms

Sleepless in Drosophila

Researchers at the University of Pennsylvania reported in Science the identification of a gene whose influence on potassium channel activity could have implications for treating insomnia and other sleep disorders. Although sleep is an essential...