21:59 , Jul 11, 2019 |  BC Innovations  |  Targets & Mechanisms

The tumor stroma rises as the newest source of immuno-oncology targets

With a spate of therapies entering the clinic, the next frontier in the fight against resistance to checkpoint inhibitors will be the stroma. The lead target marks a resurgence of interest in TGFβ, and behind...
22:58 , Oct 11, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Basal cell carcinoma (BCC) Mouse studies suggest combining LGR5, LRP6 or PORCN inhibitors with Erivedge vismodegib could help treat BCC. In two mouse models of BCC, diphtheria toxin-mediated depletion of LGR5 decreased tumor burden...
17:15 , Mar 30, 2018 |  BC Week In Review  |  Clinical News

RedX suspends Phase I/IIa of RXC004 on safety outcome

Redx Pharma plc (LSE:REDX) suspended enrollment in a Phase I/IIa trial evaluating RXC004 in patients with advanced malignancies after the first patient dosed in the trial reported "clinically significant adverse events" possibly related to on-target...
19:13 , Aug 22, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture and mouse studies identified a piperidine-maleimide-based PORCN inhibitor that could help treat breast cancer. Chemical synthesis and testing of analogs of a PORCN inhibitor tool compound in cell-based assays yielded...
15:52 , Feb 8, 2017 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular

INDICATION: Myocardial infarction (MI) Mouse studies suggest inhibiting PORCN could help treat MI. In a mouse model of MI, a PORCN inhibitor tool compound decreased scarring, heart mass and ventricular dilation and increased cardiac function...
07:00 , May 12, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: β-catenin (CTNNB1); ubiquitin specific peptidase 6 (USP6)

Cancer INDICATION: Cancer Cell culture and mouse studies suggest inhibiting Wnt/ CTNNB1 signaling could help treat nodular fasciitis, alveolar rhabdomyosarcoma and other USP6-overexpressing cancers. Screening of siRNA libraries in HEK cells and a human sarcoma...