BioCentury | Aug 10, 2017
Preclinical News

eGenesis strides toward safe pig organ transplants

...identify the 25 encoded PERV copies. Next, they designed two CRISPR guide RNAs targeting the porcine endogenous retrovirus polymerase (PERV pol)...
...develop pig embryos with both modifications (see BioCentury, March 17) . Lauren Martz eGenesis Inc. CRISPR-associated protein 9 (Cas9) Porcine endogenous retrovirus polymerase Porcine endogenous retrovirus polymerase (PERV pol)...
BioCentury | Oct 22, 2015
Distillery Therapeutics

Therapeutics: Porcine endogenous retrovirus polymerase (PERV pol); CRISPR-associated protein 9 (Cas9)

...safety of xenotransplants. In a pig kidney epithelial cell line, a CRISPR/ Cas9 system targeting PERV pol...
...the CRISPR approach to develop pig embryos lacking PERVs. (See "Transplant Xenophilia", page 10) TARGET/MARKER/PATHWAY: Porcine endogenous retrovirus polymerase (PERV pol)...
BioCentury | Oct 22, 2015
Tools & Techniques

Transplant xenophilia

...team designed an inducible CRISPR/Cas9 system to specifically target each of the 62 genes encoding PERV pol...
...human cell line with treated or untreated pig cells, and testing for the presence of PERV pol...
...Robert Koch Institute, Berlin, Germany Targets and Compounds Cas9 - CRISPR-associated protein 9 PERV pol - Porcine endogenous retrovirus polymerase...
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