BioCentury | Jun 27, 2020
Tools & Techniques

Tapping astrocytes to replace lost neurons in Parkinson’s

...RNA-binding protein PTBP1 via injection of an adeno-associated virus vector expressing small hairpin RNA against PTBP1...
...or as an antisense oligonucleotide. Targets PTBP1 - Polypyrimidine tract binding protein 1 Danielle Kopke, Staff Writer University of California San Diego Polypyrimidine tract binding protein 1 (PTBP1)...
BioCentury | Aug 2, 2019
Distillery Techniques

Genetic biomarkers for anorexia nervosa

TECHNIQUES CATEGORY: Biomarkers TECHNOLOGY: SNPs; gene profiling SNPs in eight genomic regions could predict risk of anorexia nervosa. The loci were identified in a meta-analysis of 33 genome-wide association studies (GWAS) covering 16,992 anorexic patients...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Adhesion targets emerge at ASH 2018

The next wave of targets in blood cancers and hematology will come from adhesion molecules, innate immune cells and regulators of gene expression, according to BioCentury’s analysis of emerging targets at ASH 2018. BioCentury’s analysis...
BioCentury | May 5, 2016
Distillery Techniques

Techniques: Direct reprogramming of human adult fibroblasts into mature neurons for screening neuroprotectants and generating disease models

...developing models of neurological diseases. Fibroblasts derived from healthy volunteers were reprogrammed by knockdown of polypyrimidine tract binding protein 1 (PTBP1)...
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