BioCentury | Sep 6, 2019
Regulation

Lackluster U.S. biosimilars market sparks radical recommendations

...complementary methods that examine directly the quantitative biological effects of differences in composition (such as PKs...
BioCentury | Aug 3, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: July 2017

...that could help treat S. aureus infections. University of Würzburg Distillery Therapeutics Tuberculosis Mycobacterium tuberculosis polyketide synthase...
BioCentury | Jul 3, 2017
Preclinical News

Researchers identify new TB inhibitors

...Texas A&M University and other institutions showed a benzofuran derivative inhibited the active site of polyketide synthase...
...effective against TB infection in mice. While polyketides have formed the basis for many drugs, polyketide synthase...
...essential proteins to treat bacterial infections. Mary Romeo Broad Institute of MIT and Harvard Texas A&M University Mycobacterium tuberculosis polyketide synthase...
BioCentury | Jun 25, 2015
Distillery Techniques

Techniques: Synthesis of antibacterial erythromycin analogs in engineered

...analogs with antibacterial activity. E. coli were engineered to express 16 different combinations of 24 PKS...
...testing the analogs in animal models of erythromycin-resistant pathogenic bacteria and evaluating additional combinations of PKS...
BioCentury | Oct 17, 2013
Distillery Techniques

Technology: Chemistry

...contact information Chemistry In vitro generation of branched polyketides using bacterial polyketide synthase (PKS) A bacterial PKS...
...only have the ability to generate linear polyketide structures. Chemical and structural analysis of a PKS...
...branched polyketide backbones. Next steps include further exploring the enzymatic reactions that the newly discovered PKS...
BioCentury | Oct 22, 2009
Tools & Techniques

Biosynthetic snapshot

Harnessing the therapeutic potential of natural products is hampered by limited knowledge about the identity and function of enzymes that synthesize them. A team of European researchers is looking to fill the information gap with...
BioCentury | Jun 4, 2009
Tools & Techniques

Polyketide pas de deux

...a way around the symbiosis problem. They backtracked from particular polyketide structures to the corresponding PKS...
...Nature Chemical Biology, the team described tests on whether this hypothesis could help identify the PKS...
...target each predicted PKSgene and used the primers and conventional PCR to amplify the psymberin-producing PKS...
BioCentury | Apr 23, 2009
Tools & Techniques

DNA assembly: simple and super-sized

...said. In December, Tang and colleagues reported engineering E. coli to express a fungal polyketide synthase (PKS...
BioCentury | Jan 15, 2009
Cover Story

(Back)boning up on polyketides

...These failures led Tang and colleagues to speculate that engineering E. coli to express fungal PKS...
BioCentury | Jan 8, 2009
Distillery Techniques

Technology: Drug platforms

...discovery and production of pharmaceutically relevant polyketides. Expression in Escherichia coli of a multicomponent fungal polyketide synthase...
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