17:37 , Jul 17, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Cell culture and mouse studies suggest virus-targeted delivery of defective versions of viral RNA polymerase subunits PA, PB1 and PB2 genes could help prevent or treat influenza A infection. In canine and...
03:45 , Apr 13, 2018 |  BC Innovations  |  Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...
08:00 , Mar 10, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Viral RNA polymerase PB1 subunit; viral RNA polymerase PA subunit; viral RNA-dependent RNA polymerase

Infectious disease INDICATION: Influenza virus Cell culture studies identified two inhibitors of the interaction between the viral RNA polymerase PB1 and PA subunits of influenza virus that could help treat influenza. Chemical synthesis and in...
07:00 , May 7, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Viral RNA polymerase PA subunit; viral RNA polymerase PB1 subunit

Infectious disease INDICATION: Influenza virus In vitro studies suggest inhibitors of interactions between influenza viral RNA polymerase PA and PB1 subunits could help treat influenza infection. Chemical synthesis and in vitro testing of triazolopyrimidine analogs...
07:00 , May 15, 2014 |  BC Innovations  |  Cover Story

Chromatin's rising tide

To capitalize on the full range of possible chromatin targets in and beyond oncology, industry and academia will need to delve deeper into how chromatin regulation is altered in disease, create tools that can reliably...
08:00 , Mar 6, 2014 |  BC Innovations  |  Targets & Mechanisms

Depending on SWI/SNF

Gain-of-function alterations in histone-modifying proteins drive multiple cancers and are now being targeted by compounds in the clinic, 1 but loss-of-function mutations, which are more frequently found in chromatin remodelers, remain largely intractable. Separate teams...
08:00 , Jan 23, 2014 |  BC Innovations  |  Tools & Techniques

Diagnosing narcolepsy

A new way to diagnose narcolepsy using T cells 1 has piqued the interest of at least two companies- Jazz Pharmaceuticals plc and GlaxoSmithKline plc . The former could use the results to help diagnose...
07:00 , Jul 11, 2011 |  BioCentury  |  Emerging Company Profile

Savira: Capping influenza

Savira Pharmaceuticals GmbH is taking a page out of the HIV playbook by targeting influenza's viral polymerase . The company believes its compounds can provide the efficacy of neuraminidase inhibitors but with less potential for...
07:00 , Jul 15, 2010 |  BC Innovations  |  Targets & Mechanisms

Fixing vascular leak in IL-2 immunotherapy

Neither of the two marketed IL-2 immunotherapies for cancer is widely used due to potentially severe side effects such as vascular leak syndrome. Now, Swiss researchers have shown that lung endothelial cells magnify IL-2's toxicity....
07:00 , Jul 15, 2010 |  BC Innovations  |  Tools & Techniques

A less fit flu virus

A team of researchers from the State University of New York at Stony Brook has used a computer-guided approach to engineer live attenuated influenza strains that protect mice from wild-type flu virus. 1 The researchers...