BioCentury | Nov 17, 2011
Targets & Mechanisms

SEMA4D in osteoporosis

...suppress bone formation. Subsequent mouse studies fleshed out a mechanism: osteoclast-derived Sema4d binds its receptor, plexin B1 (Plxnb1)...
...cleavage [ a ]. Active SEMA4D binds plexin B1 (PLXNB1) on the osteoblast surface [ b ]. PLXNB1...
...PLXNB1 phosphorylation (P). Rho guanine exchange factors (RhoGEFs) bind to and are activated by phosphorylated PLXNB1...
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