BioCentury | Sep 26, 2019
Financial News

ZielBio raises $25M series A to advance two new cancer targets

...ADC against the target, but in the process we figured out that the cell surface plectin...
...Morningside’s Jason Dinges and Partners’ Meredith Fisher joined ZielBio’s board. Targets: CSP1 - Cell surface plectin...
BioCentury | Mar 28, 2018
Distillery Techniques

Biomarkers

...disease and SNPs on nine genomic loci, including transforming growth factor α (TGFA) (rs3771501) and plectin (PLEC)...
...doi:10.1038/s41588-018-0079-y CONTACT: Eleftheria Zeggini, Wellcome Trust Sanger Institute, Hinxton, U.K. email: eleftheria@sanger.ac.uk Sandi Wong Wellcome Trust Sanger Institute Plectin (PLEC) Transforming...
BioCentury | May 12, 2016
Distillery Techniques

Techniques: Plectin (PLEC)-targeting nanoparticle to deliver cancer therapies to pancreatic ductal adenocarcinoma (PDAC) tumors

...Drug delivery TECHNOLOGY: Nanoparticles Polymer nanoparticles linked to a PLEC-targeting peptide could be used to deliver...
...PDAC tumors. The nanoparticles were composed of poly(lactic-co-glycolic acid) (PLGA) polymers, a peptide that bound PLEC...
...growth compared with compound-loaded nanoparticles lacking the PLEC-binding peptide. Next steps could include testing the PLEC-targeting...
BioCentury | Dec 19, 2013
Distillery Therapeutics

Indication: Cancer

...Publication and contact information Cancer Pancreatic cancer Plectin (PLEC) In vitro and mouse studies suggest inhibiting PLEC...
...of PLEC and produced exosomes containing increased levels of PLEC. In the cancer cell lines, PLEC...
...shRNA. In both immunocompromised and immunocompetent mice, injection of a human pancreatic cell line after PLEC...
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