BioCentury | Jul 12, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: June 2018

...Description Company or Institution Notes Therapeutic targets Cancer Breast cancer; non-small cell lung cancer (NSCLC) Pleckstrin homology...
BioCentury | Jun 21, 2018
Translation in Brief

PHIP the script

...Research Institute (CPMCRI) and the University of California San Francisco first identified a role for pleckstrin homology...
...homolog deleted on chromosome ten (PTEN) (MMAC1) (TEP1) Phosphoinositide 3-kinase (PI3K) catalytic subunit alpha polypeptide (PI3KCA) (p110alpha) Pleckstrin homology...
BioCentury | Jun 6, 2018
Distillery Therapeutics


...developing and testing small molecule PHIP inhibitors in animal models of TNBC and NSCLC. TARGET/MARKER/PATHWAY: Pleckstrin homology...
BioCentury | Apr 4, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: March 2018 BEST1 mutations. University of Pennsylvania Distillery Therapeutics Biomarkers Cancer Cancer; breast cancer; endometrial cancer Pleckstrin homology...
BioCentury | Mar 13, 2018
Distillery Techniques


...have the compound in clinical testing for multiple other cancers. DESCRIPTION: Tumor cell levels of pleckstrin homology...
...receptor (FGFR) Fibroblast growth factor (FGF) receptor 1 (FGFR1) (CD331) Keratinocyte growth factor (KGF) receptor (KGFR) (FGFR2) (CD332) Pleckstrin homology...
BioCentury | Nov 30, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: November 2017

...truncated form could help treat frontotemporal dementia (FTD). Massachusetts Institute of Technology Distillery Therapeutics Neurology Pleckstrin homology...
BioCentury | Nov 15, 2017
Distillery Therapeutics


...activators in models of PLEKHG5-mutant motor neuron disease. TARGET/MARKER/PATHWAY: RAB26 member RAS oncogene family (RAB26); pleckstrin homology... CONTACT: Michael Sendtner, University Hospital Würzburg, Würzburg, Germany email: Hongjiang Li University Hospital Wuerzburg University of Bielefeld Pleckstrin homology...
BioCentury | Jan 25, 2017
Distillery Therapeutics


...growth. Next steps could include identifying and testing PHLDB3 inhibitors in additional cancer models. TARGET/MARKER/PATHWAY: Pleckstrin homology...
...Lu, Tulane University School of Medicine, New Orleans, La. email: Hongjiang Li Tulane University School of Medicine Pleckstrin homology...
BioCentury | Dec 3, 2015
Distillery Therapeutics

Therapeutics: Pleckstrin homology domain containing family A member 7 (PLEKHA7)

...could include developing and testing inhibitors of PLEKHA7 in models of S. aureus infection. TARGET/MARKER/PATHWAY: Pleckstrin homology...
BioCentury | Dec 6, 2012
Distillery Therapeutics

Indication: Cancer

...treatment decisions. In a mouse lymphoid cell line, expression of Akt1 with mutations in the pleckstrin homology...
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