BioCentury | Nov 1, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: October 2017

...help treat malaria. Washington University School of Medicine in St. Louis Distillery Therapeutics P. falciparum plasmepsin X ( P. falciparum plasmepsin X...
BioCentury | Oct 31, 2017
Distillery Therapeutics

Infectious disease

...INDICATION: Malaria Cell culture studies suggest inhibiting P. falciparum plasmepsin IX and P. falciparum plasmepsin X could help treat...
...in animal models of malaria. TARGET/MARKER/PATHWAY: Plasmodium falciparum plasmepsin IX ( P. falciparum plasmepsin IX); P. falciparum plasmepsin X...
...dgoldberg@wustl.edu Claire Quang Washington University School of Medicine in St. Louis Plasmodium falciparum plasmepsin IX (P. falciparum plasmepsin IX) Plasmodium falciparum plasmepsin X (P. falciparum plasmepsin X)...
BioCentury | Jan 7, 2016
Distillery Therapeutics

Therapeutics: P. falciparum plasmepsin I; P. falciparum plasmepsin II; P. falciparum plasmepsin IV

Infectious disease INDICATION: Malaria Cell culture studies identified aminoquinazolinone-based inhibitors of Plasmodium falciparum plasmepsins I, II and IV that could help treat malaria. Chemical synthesis and in vitro testing of aminoquinazolinone analogs yielded multiple compounds...
BioCentury | Feb 18, 2010
Distillery Therapeutics

Indication: Indication

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum plasmepsin V (PMV; PF13_0133) Cell culture studies suggest that inhibiting PMV could help treat malaria infection. In vitro assays showed that...
BioCentury | Oct 15, 2009
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmepsin (Plasmodium falciparum) In vitro studies identified a plasmepsin inhibitor that could aid in the development of new treatments for malaria. An affinity-based...
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