BioCentury | May 6, 2020
Product Development

May 5 Quick Takes: Data propel Adverum, TG, Akebia stocks; plus Tolmar, SRI-Exscientia, Sino-GeoVax

...Gonadotropin releasing hormone 1 Target2 HIF-PH (EGLN) - Hypoxia-inducible factor prolyl hydroxylase PGF (PLGF) - Placental growth factor...
BioCentury | May 6, 2020
Product Development

Pandemic seen weighing on Eylea as Regeneron reports consensus-beating quarter, positive PD-1 data

...$1.13 billion. Eylea is a human fusion protein that binds all forms of VEGF-A and PGF...
...submissions this year. Targets PD-1 (PDCD1; CD279) - Programmed cell death 1 PGF (PLGF) - Placental growth factor...
BioCentury | Feb 11, 2020
Product Development

Adverum gains on Phase I data showing efficacy for wet AMD gene therapy

...injection, the same route for standard-of-care aflibercept. Aflibercept is a fusion protein binding VEGF-A and PGF...
...testing, but Oxford has not announced plans for Phase II testing. Targets PGF (PLGF) - Placental growth factor...
...Vascular endothelial growth factor A Sandi Wong, Assistant Editor ADVM-022 (AAV.7m8-aflibercept) Adverum Biotechnologies Inc. Vascular endothelial growth factor A (VEGF-A) Placental growth factor (PGF) (PLGF) wet...
BioCentury | Dec 13, 2019
Company News

Novartis gains CHMP support for Eylea competitor in wet AMD

...dosing every eight weeks. Bayer AG (Xetra:BAYN) has ex-U.S. rights to Eylea and markets the PGF...
...diagnosed multiple myeloma in adults eligible for autologous stem cell transplant. Targets: PGF (PLGF) - Placental growth factor...
...factor A Hongjiang Li, Staff Writer Relebactam/imipenem/cilastatin FDC adalimumab Darzalex, daratumumab (JNJ-54767414, humax-cd38) Novartis AG Merck & Co. Inc. Pfizer Inc. Johnson & Johnson Placental growth factor (PGF) (PLGF) Transthyretin...
BioCentury | Aug 20, 2019
Clinical News

Aug. 20 Clinical Quick Takes: Oxurion misses in Phase II macular edema study; plus NuCana and Moleculin

...trial in 70 patients with diabetic macular edema. THR-317 is a recombinant human mAb against PGF...
...MD Anderson Cancer Center to treat adult patients with brain cancer. Targets: PGF (PLGF) - Placental growth factor...
...factor A Mary Romeo, Assistant Editor and Paul Bonanos, Associate Editor Acelarin (MTL-007, NUC-1031) THR-317 WP1066 Moleculin Biotech Inc. NuCana plc Oxurion N.V. Placental growth factor (PGF) (PLGF) Signal...
BioCentury | Jun 27, 2019
Product Development

Gene therapy’s next frontier lies beyond rare, monogenic diseases

...include Regeneron Pharmaceutical Inc.’s Eylea aflibercept, a fusion protein injected bimonthly that binds VEGF-A and PGF...
...Mass. Targets DDC (AADC) - Dopa decarboxylase KCNA1 - Potassium channel Kv1.1 PGF (PLGF) - Placental growth factor...
BioCentury | May 11, 2019
Product Development

Now grown up, independent biotechs bulk up their platforms with more modalities

...of Libtayo cemiplimab-RWLC. Eylea is a fusion protein that blocks all forms of VEGF-A and PGF...
...16 virus HpV16gp2 - E7 transforming protein of HPV type 16 virus PLGF - Placental growth factor (PGF...
BioCentury | Apr 15, 2019
Company News

FDA accepts BLA for Novartis' AMD therapy

...Regeneron. The drug is a human fusion protein that binds all forms of VEGF-A and PGF...
...after market close. Regeneron was off $7.44 to $375.50 on Monday. Targets: PGF (PLGF) - Placental growth factor...
BioCentury | Nov 9, 2018
Clinical News

Adverum reviewing capsid after discontinuing AAT gene therapy

...Aflibercept is a human fusion protein that binds all forms of VEGF-A and placental growth factor (PGF; PLGF...
BioCentury | Nov 2, 2018
Clinical News

Genentech's faricimab improves BCVA in Phase II for wet AMD

...Eylea is a human fusion protein that binds all forms of VEGF-A and placental growth factor (PGF; PLGF...
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