BioCentury | Oct 4, 2019
Finance

Biotech down again in 3Q19

...the 90% plunge by Neurotrope Inc. (NASDAQ:NTRP), which announced September 9 that its Bryostatin-1, a PKCE...
...three other indications. Targets IL2RB (CD122) - Interleukin-2 receptor beta chain PARP - Poly(ADP-ribose) polymerase PKCE...
BioCentury | Sep 9, 2019
Clinical News

Sept. 9 Clinical Quick Takes: Translate to discontinue enzyme deficiency candidate; plus Janssen, Neurotrope, AMT and Cassava

...vs. placebo in a Phase II trial to treat moderate to severe Alzheimer’s disease. The PKCE...
...San Diego in December. Targets: CFTR - Cystic fibrosis transmembrane conductance regulator; IL-10 - Interleukin10; PKCE...
...Staff Writer MRT5201 PTI-125 Spravato, esketamine (jnj-54135419) Synthetic Bryostatin-1 Applied Molecular Transport LLC Cassava Sciences Inc. Janssen Johnson & Johnson Neurotrope Inc. Translate Bio Inc. Interleukin-10 (IL-10) Protein kinase C (PKC) epsilon (PKCE) AMT-101 ornithine...
BioCentury | Feb 28, 2018
Distillery Therapeutics

Autoimmune disease

...INDICATION: Multiple sclerosis (MS) Mouse studies suggest the PKCE activator bryostatin-1 could help treat MS. In...
...the compound in preclinical testing to treat fragile X syndrome. TARGET/MARKER/PATHWAY: Protein kinase C ε (PKCE...
...Md. email: ssnyder@jhmi.edu CONTACT: Paul Kim, same affiliation as above email: pmkim@jhmi.edu Elizabeth S. Eaton Johns Hopkins University Protein kinase C (PKC) epsilon (PKCE) Multiple...
BioCentury | Oct 17, 2017
Distillery Techniques

Chemistry

...Stanford, Calif. email: wenderp@stanford.edu Hongjiang Li Stanford University Protein kinase C (PKC) beta (PRKCB) Protein kinase C (PKC) delta (PRKCD) Protein kinase C (PKC) epsilon (PKCE)...
BioCentury | May 23, 2017
Distillery Therapeutics

Cancer

...INDICATION: Melanoma Cell culture studies suggest inhibiting PRKCD , PKCE or RASGRP3 could help treat GNAQ...
...compared with normal PRKCD and PKCE expression. Next steps could include identifying and testing PRKCD, PKCE...
...models of GNAQ-mutant uveal melanoma. TARGET/MARKER/PATHWAY: Protein kinase C δ (PRKCD); protein kinase C ε (PKCE...
BioCentury | May 5, 2017
Clinical News

Neurotrope reports mixed Ph III AD data for Bryostatin-1

...a protein kinase C (PKC) epsilon (PKCE) activator. Neurotrope Inc. (NASDAQ:NTRP), New York, N.Y. Product: Bryostatin-1 Business: Neurology Molecular target: Protein kinase C (PKC) epsilon (PKCE)...
...activator. Neurotrope Inc. (NASDAQ:NTRP), New York, N.Y. Product: Bryostatin-1 Business: Neurology Molecular target: Protein kinase C (PKC) epsilon (PKCE) Description: PKCE...
...of Daily Living-Inventory Severe Impairment Version (ADCS-ADL-SIV) Status: Phase II data Milestone: NA Jaime De Leon Neurotrope Inc. Protein kinase C (PKC) epsilon (PKCE) Bryostatin-1...
BioCentury | May 1, 2017
Clinical News

Neurotrope hammered after Alzheimer's readout

...consisted of the mITT patients who completed a 13-week assessment. The treatment group received the protein kinase C (PKC) epsilon (PKCE)...
...discuss a clinical path forward for the compound, including an open label extension study. Becky Simon Neurotrope Inc. Protein kinase C (PKC) epsilon (PKCE) Alzheimer's...
BioCentury | Feb 3, 2017
Company News

Stanford, Neurotrope deal

...to disclose financial terms, and Stanford did not respond to inquiries. Neurotrope is evaluating the protein kinase C (PKC) epsilon (PKCE)...
BioCentury | Nov 23, 2016
Clinical News

Bryostatin-1: Completed Ph II enrollment

...12 weeks. Neurotrope Inc. (OTCQB:NTRP), Newark, N.J. Product: Bryostatin-1 Business: Neurology Molecular target: Protein kinase C (PKC) epsilon (PKCE) Description: PKCE...
...Mini-Mental State Exam (MMSE) Status: Completed Phase II enrollment Milestone: Phase II data (04/2017) Julian Zhu Bryostatin-1 Neurotrope Inc. Protein kinase C (PKC) epsilon (PKCE)...
BioCentury | Aug 22, 2016
Clinical News

Bryostatin-1: Phase IIb amended

...early 2Q17. Neurotrope Inc. (OTCQB:NTRP), Newark, N.J. Product: Bryostatin-1 Business: Neurology Molecular target: Protein kinase C (PKC) epsilon (PKCE) Description: Protein kinase C (PKC) epsilon (PKCE)...
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