20:31 , Jan 25, 2018 |  BC Innovations  |  Translation in Brief

Melanoma vs. melanoma

A Northwestern University team has discovered that some non-metastatic melanoma cells carry a signal, pigment epithelium derived factor (PEDF), that can induce immune-mediated killing of metastatic cells, pointing toward a new immunotherapeutic strategy for the...
01:15 , Dec 13, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Melanoma Mouse studies suggest PEDF-positive exosomes from primary tumors could help treat metastatic melanoma. In allogeneic and xenograft mouse models of metastatic melanoma, treatment before tumor induction with PEDF-positive exosomes from mouse and human...
08:00 , Nov 16, 2015 |  BioCentury  |  Emerging Company Profile

Bridge to POC

BRIM Biotechnology Inc. has assembled a team of translational science veterans to fill what it sees as a gap in Taiwanese drug development capabilities. The company plans to bring in preclinical projects with global commercialization...
07:00 , Aug 19, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Liver cancer IL-12; granulocyte macrophage colony-stimulating factor (CSF2; GM-CSF); pigment epithelium derived factor (SERPINF1; PEDF); endostatin (ED) A study in woodchucks suggests that a...
07:00 , Aug 6, 2009 |  BC Innovations  |  Targets & Mechanisms

Signaling insulin resistance in obesity

Researchers at Monash University have made a case for PEDF as a missing link between obesity and insulin resistance that leads to diabetes. 1 However, the adipose-secreted cytokine has many biological roles, which could make...
07:00 , Jul 23, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Various

Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Diabetes; obesity; metabolic disorders Pigment epithelium-derived factor (PEDF; SERPINF1) In vitro and mouse studies suggest that antagonizing PEDF could help treat obesity-induced insulin resistance that...
08:00 , Mar 2, 2009 |  BioCentury  |  Product Development

Wet AMD pipeline

Wet AMD pipeline...
07:00 , Oct 16, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Ophthalmic disease Ophthalmic G protein-coupled receptor 143 (GPR143; ocular albinism 1; OA1); serpin peptidase inhibitor, clade F (a2 antiplasmin, pigment epithelium...
08:00 , Jan 29, 2007 |  BioCentury  |  Product Development

Back-of-the-eye pipeline

Back-of-the-eye pipeline...
08:00 , Jan 29, 2007 |  BioCentury  |  Product Development

Optical focus

For years, the ophthalmic space was more or less moribund as far as biotech was concerned, populated mainly by old-line companies peddling old-line treatments. But both the aging of the population and the rise in...