BioCentury | Mar 13, 2019
Distillery Therapeutics

Inhibiting PIEZO1 for nerve damage

...Therapeutics Inc. and Akashi Therapeutics Inc. have AT-300, a small molecule inhibitor of PIEZO1 and PIEZO2...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Adhesion targets emerge at ASH 2018

The next wave of targets in blood cancers and hematology will come from adhesion molecules, innate immune cells and regulators of gene expression, according to BioCentury’s analysis of emerging targets at ASH 2018. BioCentury’s analysis...
BioCentury | May 9, 2018
Distillery Therapeutics

Gastrointestinal

INDICATION: Pancreatitis Mouse studies suggest PIEZO1 inhibition could help treat pancreatitis. In a mouse model of pressure-induced acute pancreatitis, pancreatic acinar cell-specific knockout of PIEZO1 or the PIEZO1 inhibitor AT-300 decreased histological disease scores and...
BioCentury | Apr 3, 2018
Distillery Therapeutics

Infectious disease

INDICATION: Malaria Mouse experiments suggest enhancing PIEZO1 activity could help treat malaria. In primary human erythrocyte-based assays of Plasmodium falciparum growth, parasite proliferation was lower in erythrocytes from donors harboring gain-of-function mutations on PIEZO1 than...
BioCentury | Mar 23, 2018
Preclinical News

PIEZO1 confers resistance to malaria

Scientists at The Scripps Research Institute published a paper in Cell suggesting that a gain-of-function mutation in Piezo-type mechanosensitive ion channel component 1 (PIEZO1) could provide resistance against malaria. Gain-of-function PIEZO1 mutations lead to hereditary...
BioCentury | Jan 25, 2018
Translation in Brief

Remote-controlled CARs

A three-way academic collaboration has developed an ultrasound-based method for controlling both when and where CAR T cells are active. The technology could move the field a step beyond designs that incorporate only on- or...
BioCentury | Jan 11, 2017
Distillery Therapeutics

Neurology

INDICATION: Pain Mouse studies identified a STOML3 inhibitor that could help treat neuropathic pain associated with nerve injury and diabetes. Screening of a small molecule library for inhibitors of mouse and human STOML3 dimerization followed...
BioCentury | Dec 11, 2014
Targets & Mechanisms

PIEZO de resistance

...A pair of recently identified calcium channels- PIEZO1 and PIEZO2-control the response of cartilage to heavy...
...divide. The researchers focused on PIEZO1 ( piezo-type mechanosensitive ion channel component 1 ) and PIEZO2-whose...
...knee joints and in primary chondrocytes from pigs and humans. To test whether Piezo1 and Piezo2...
BioCentury | Dec 11, 2014
Distillery Therapeutics

Indication: Musculoskeletal disease

...ion channel component 1 (PIEZO1); PIEZO2 Cell and tissue culture studies suggest inhibiting PIEZO1 and PIEZO2...
...could prevent load-induced articular cartilage damage. In mice, chondrocytes expressed higher levels of Piezo1 and Piezo2...
...with applied pressure, and siRNA against PIEZO1 or PIEZO2 or treatment with the PIEZO1 and PIEZO2...
BioCentury | Sep 1, 2014
Clinical News

MMI-0100: Phase I started

Moerae Matrix began a double-blind, placebo-controlled, Dutch Phase I trial to evaluate ascending doses of inhaled MMI-0100 in up to 48 healthy volunteers. MMI-0100 uses MicroDose’s inhaler technology, which uses a piezo vibrator to de-aggregate...
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