07:00 , Oct 15, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Phospholipase D2 (PLD2)

Infectious disease INDICATION: Sepsis Mouse studies suggest inhibiting PLD2 could help treat sepsis. In two mouse models of sepsis, PLD2 knockout or a tool compound that inhibited PLD2 decreased levels of proinflammatory cytokines and chemokines...
08:00 , Jan 13, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD) Phospholipase D2 (PLD2) Studies in mice suggest that inhibiting PLD2 could help prevent b-amyloid (Ab)-associated toxicity to treat...
08:00 , Jan 29, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Phospholipase D (PLD); PLD1; PLD2 An SAR study identified a series of isoform-selective PLD inhibitors that could be useful for...