07:00 , Aug 27, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Phospholipase D1 (PLD1)

Cancer INDICATION: Colorectal cancer Mouse and patient sample studies suggest inhibiting PLD1 could help treat colorectal cancer. In colorectal cancer patients, levels of PLD1 mRNA were higher in tumors than in surrounding normal tissues and...
07:00 , May 6, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Ophthalmic disease Phospholipase D1, phosphatidylcholine-specific (PLD1); protein kinase C γ (PRKCG) In vitro and mouse studies suggest that inhibiting PLD1 or PRKCG could prevent...
08:00 , Jan 29, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Phospholipase D (PLD); PLD1; PLD2 An SAR study identified a series of isoform-selective PLD inhibitors that could be useful for...