...biobank in a HEK cell-based assay of response to rhinoviral infection identified a mutation in phospholipase A2 group XVI (PLA2G16)...
...43kDa (GJA1) (CX43) (connexin-43) Hemopoietic cell kinase (HCK) MDS1 and EVI1 complex locus (MECOM) Phosphodiesterase-I beta (ENPP3) (NPP3) (CD203c) Phospholipase A2 group XVI (PLA2G16) Phospholipase...

...group performed a genome-wide forward screen of Haplobank cells for resistance to rhinovirus and identified phospholipase A2 group XVI (PLA2G16)...
...immune response to rhinovirus infection. In human embryonic kidney (HEK) cells infected with rhinovirus, inactivating PLA2G16...
...to discover and develop small molecules against PLA2G16 to treat viral infections. The partners have PLA2G16...

...INDICATION: Viral infection Cell culture and mouse studies suggest inhibiting PLA2G16 could help treat picornaviral infections...
...increased survival. Next steps by Haplogen GmbH and Evotec AG include developing PLA2G16 inhibitors. TARGET/MARKER/PATHWAY: Phospholipase A2 group XVI (PLA2G16)...
...2017 doi:10.1038/nature21032 CONTACT: Thijn Brummelkamp, Netherlands Cancer Institute, Amsterdam, the Netherlands email: t.brummelkamp@nki.nl Winnie Pong Netherlands Cancer Institute Phospholipase A2 group XVI (PLA2G16) Viral...

...Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Obesity Phospholipase A2, group XVI (PLA2G16...