BioCentury | Jul 13, 2020
Targets & Mechanisms

Verge puts ALS target through COVID-19 paces, leaning on preclinical partners

...After a drug repositioning screen flagged Verge’s ALS target PIKFYVE as an Achilles heel for COVID-19...
...Genomics Inc.’s new COVID-19 program to leapfrog its lead candidate into the clinic. Verge’s original PIKFYVE...
...collaboration.” Targets ACE2 - Angiotensin-converting enzyme 2 PIKFYVE - Phosphoinositide kinase FYVE finger containing Karen Tkach Tuzman, Associate Editor Verge Genomics Inc. Phosphoinositide kinase FYVE finger containing (PIKFYVE) cov19count preclinical...
BioCentury | Dec 8, 2017
Targets & Mechanisms

Epiphenomena at ASH

...5 1 Nicotinamide phosphoribosyltransferase (NamPRT; NAMPT) 4 1 NK2 homeobox 1 (NKX2-1; TTF1) 4 1 Phosphoinositide kinase FYVE finger containing (PIKFYVE)...
BioCentury | Aug 29, 2013
Distillery Therapeutics

Indication: Autoimmune disease

...Autoimmune disease Autoimmune disease Phosphoinositide kinase FYVE finger containing (PIKFYVE) Cell culture studies identified the molecular target of apilimod as PIKFYVE...
...production of IL-12 and IL-23, but its molecular target was unknown. In vitro, apilimod inhibited PIKFYVE...
...with an IC50 value of 14 nM. In cell culture, small hairpin RNA-mediated knockdown of PIKFYVE...
Items per page:
1 - 3 of 3