BioCentury | May 23, 2018
Distillery Therapeutics

Cancer

...peptide to enable tumor cell penetration and loaded with two compounds -- a tool compound PI3KCD...
...T cell therapies in other solid tumor models. TARGET/MARKER/PATHWAY: Phosphoinositide 3-kinase catalytic subunit δ polypeptide (PI3KCD...
...Stephan, Fred Hutchinson Cancer Research Center, Seattle, Wash. email: mstephan@fredhutch.org Elizabeth S. Eaton Fred Hutchinson Cancer Research Center Phosphoinositide 3-kinase (PI3K) catalytic subunit delta polypeptide (PI3KCD) (p110delta) Solid...
BioCentury | May 16, 2018
Preclinical News

Nanoparticle pretreatment could boost solid tumor CAR T therapy

...a liposomal nanoparticle to carry two agents: a small molecule tool inhibitor of phosphoinositide 3-kinase (PI3K) catalytic subunit delta polypeptide (PI3KCD; p110delta...
...Cancer Research Center University of Washington Epidermal growth factor receptor variant III (EGFRvIII) Integrin alpha(V) (CD51) Natural killer T cells Phosphoinositide 3-kinase (PI3K) catalytic subunit delta polypeptide (PI3KCD) (p110delta) Receptor...
BioCentury | Aug 16, 2017
Distillery Techniques

Biomarkers

...of mRNA splice variants could help diagnose prostate cancer in African-Americans and levels of one PI3KCD...
...In tumor samples from 494 non-racially stratified prostate cancer patients, high levels of the PI3KCD...
...of mRNA splice variants to diagnose prostate cancer and phosphoinositide 3-kinase catalytic subunit δ polypeptide (PI3KCD...
BioCentury | Nov 3, 2016
Translation in Brief

One plus one equals four

...dual inhibitor of phosphoinositide 3-kinase catalytic subunit β polypeptide ( PI3KCB ; p110β ) and PI3KCD...
...3-kinase (PI3K) catalytic subunit alpha polypeptide (PI3KCA) (p110alpha) Phosphoinositide 3-kinase (PI3K) catalytic subunit beta polypeptide (PI3KCB) (p110beta) Phosphoinositide 3-kinase (PI3K) catalytic subunit delta polypeptide (PI3KCD) (P110delta)...
BioCentury | Oct 17, 2016
Clinical News

KA2237: Phase I started

...PI3KCB) (p110beta) ; Phosphoinositide 3-kinase (PI3K) catalytic subunit delta polypeptide (PI3KCD) (p110delta) Description: Phosphoinositide 3-kinase (PI3K) catalytic subunit beta polypeptide (PI3KCB; p110beta) and PI3KCD...
BioCentury | Jul 10, 2014
Distillery Therapeutics

Indication: Cancer

...Publication and contact information Cancer Solid tumors Phosphoinositide 3-kinase-d (PI3Kd); phosphoinositide 3-kinase catalytic subunit d-polypeptide (PI3KCD...
BioCentury | Jun 26, 2014
Targets & Mechanisms

PI3K inhibition: solid immunotherapy

...by Ali et al., inhibition of phosphoinositide 3-kinase-d (PI3Kd) or the PI3K catalytic subunit d-polypeptide (PI3KCD...
BioCentury | Nov 14, 2013
Distillery Therapeutics

Indication: Autoimmune disease

...Publication and contact information Autoimmune disease Primary immunodeficiency disease (PID) Phosphoinositide 3-kinase catalytic subunit d-polypeptide (PI3KCD...
BioCentury | Sep 21, 2009
Emerging Company Profile

Xcovery: Taking tox out

...inhibitor; X-319, an inhibitor of phosphoinositide 3-kinase (PI3K) catalytic subunit alpha polypeptide (PI3KCA); and the PI3KCD...
Items per page:
1 - 9 of 9