BioCentury | Nov 14, 2019
Targets & Mechanisms

New roles for HDACs in the cytoplasm and muscle disorders

...Histone deacetylase 3 HspA8 (HSC70) - Heat shock 70 kDa protein 8 PGC-1α (PPARGC1A) - Peroxisome proliferation activated receptor (PPAR) gamma...
BioCentury | Aug 1, 2019
Distillery Therapeutics

ARID5A as a therapy for obesity

...online July 9, 2019 doi:10.1073/pnas.1906712116 CONTACT: Tadamitsu Kishimoto, Osaka University, Osaka, Japan email: kishimoto@ifrec.osaka-u.ac.jp Claire Quang Osaka University Peroxisome proliferation activated receptor (PPAR) gamma Obesity...
BioCentury | Apr 5, 2019
Targets & Mechanisms

Breaking up Hippo to tame proliferation

...2 (MAP2K2) (MEK2) Neurofibromin 2 (NF2) (Merlin) Peroxisome proliferation activated receptor (PPAR) alpha Peroxisome proliferation activated receptor (PPAR) delta Peroxisome proliferation activated receptor (PPAR) gamma Serine/threonine...
BioCentury | Feb 22, 2019
Clinical News

Inventiva discontinues lanifibranor for systemic sclerosis

...discontinued Milestone: NA Brian Moy lanifibranor (iva337) Inventiva S.A. Peroxisome proliferation activated receptor (PPAR) alpha Peroxisome proliferation activated receptor (PPAR) delta Peroxisome proliferation activated receptor (PPAR) gamma Non-alcoholic...
BioCentury | Oct 5, 2018
Financial News

Minoryx raises €21M series B, advances MIN-102

...of MIN-102 in a second orphan CNS disease. Minoryx Therapeutics S.L., Mataro, Spain Shannon Lehnbeuter MIN-102 Minoryx Therapeutics S.L. Peroxisome proliferation activated receptor (PPAR) gamma...
BioCentury | May 3, 2018
Distillery Therapeutics

Cancer

...Dana-Farber Cancer Institute, Boston, Mass. email: glenn.dranoff@novartis.com Jennie Walters Avandia, rosiglitazone Dana-Farber Cancer Institute Novartis AG Granulocyte colony-stimulating factor (G-CSF) (CSF3) Peroxisome proliferation activated receptor (PPAR) gamma...
BioCentury | Apr 20, 2018
Financial News

Inventiva raises €35.5M in private placement

...Daix, France Chris Lieu lanifibranor (iva337) Odiparcil (IVA336) Inventiva S.A. Peroxisome proliferation activated receptor (PPAR) alpha Peroxisome proliferation activated receptor (PPAR) delta Peroxisome proliferation activated receptor (PPAR) gamma Non-alcoholic...
BioCentury | Apr 13, 2018
Financial News

Inventiva raises €35.5M in private placement

...to €7.30. Chris Lieu lanifibranor (iva337) Odiparcil (IVA336) Inventiva S.A. Peroxisome proliferation activated receptor (PPAR) alpha Peroxisome proliferation activated receptor (PPAR) delta Peroxisome proliferation activated receptor (PPAR) gamma Non-alcoholic...
BioCentury | Mar 16, 2018
Emerging Company Profile

Cirius safety

...congestive heart failure and edema. While TZDs were initially thought to work by agonizing peroxisome proliferation activated receptor gamma (PPAR gamma...
...duct-specific knockout of the PPAR gamma gene buffered Avandia-induced fluid retention in mice compared with normal PPAR gamma...
...alternative to PPAR gamma agonists. “All the first-generation TZDs also bound to MPC in addition to PPAR gamma,”...
BioCentury | Feb 2, 2018
Clinical News

Takeda, Zinfandel's AD test fails to deliver

...and in AD Cooperative Study-Activities of Daily Living-Prevention Instrument (ADCS-ADL-PI). Pioglitazone is a thiazolidinedione (TZD) PPAR gamma...
...Tokyo:4502), Osaka, Japan Product: Actos pioglitazone (AD-4833) Business: Neurology Molecular target: PPAR gamma Description: Thiazolidinedione (TZD) PPAR gamma...
...Daily Living-Prevention Instrument (ADCS-ADL-PI) Status: Phase III discontinued Milestone: NA Meghan Sullivan Actos pioglitazone Takeda Pharmaceutical Co. Ltd. Zinfandel Pharmaceuticals Inc. Peroxisome proliferation activated receptor (PPAR) gamma...
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