BioCentury | May 28, 2019
Distillery Therapeutics

TSPO agonist to treat Parkinson's disease

...in cells expressing TSPO compared with TSPO-knockout cells. In a mouse model of PD, the TSPO...
...has TRO40303, a TSPO ligand, in Phase II testing for ischemia/reperfusion injury. TARGET/MARKER/PATHWAY: Peripheral benzodiazepine receptor (TSPO; PBR...
...German Center for Neurodegenerative Diseases, Bonn, Germany email: anja.schneider@dzne.de Chris Lieu German Center for Neurodegenerative Diseases Peripheral benzodiazepine receptor (TSPO) (PBR) Parkinson's...
BioCentury | May 12, 2016
Distillery Therapeutics

Therapeutics: Peripheral benzodiazepine receptor (TSPO; PBR); Mdm2 p53 binding protein homolog (MDM2; HDM2)

...Cancer INDICATION: Brain cancer In vitro studies identified an inhibitor of MDM2 /p53 binding and TSPO...
...that bound MDM2 to inhibit MDM2-p53 binding with an IC50 of 4.3 nM and inhibited TSPO...
...Next steps could include testing the compound in animal models of glioblastoma. TARGET/MARKER/PATHWAY: Peripheral benzodiazepine receptor (TSPO; PBR...
BioCentury | Mar 14, 2016
Emerging Company Profile

AMO's CNS ammunition

...a farnesylated dibenzodiazepinone in development for fragile X. AMO-01 targets the peripheral benzodiazepine receptor ( TSPO ; PBR...
...least three compounds are in the clinic to treat fragile X, none of which target TSPO...
BioCentury | Jan 19, 2015
Company News

Trophos, Roche deal

...treat multiple sclerosis (MS). The pharma also gains TRO40303 , a peripheral benzodiazepine receptor ( TSPO ; PBR...
BioCentury | Oct 7, 2013
Clinical News

TRO40303: Phase II ongoing

...Marseille, France Product: TRO40303 Business: Cardiovascular Molecular target: Peripheral benzodiazepine receptor (TSPO) (PBR) Description: Peripheral benzodiazepine receptor (TSPO; PBR...
BioCentury | Jun 6, 2013
Distillery Therapeutics

Indication: Neurology

...AD) Peripheral benzodiazepine receptor (TSPO; PBR) Mouse studies suggest TSPO ligands could be used to treat AD. TSPO...
...both young adult and aged adult transgenic mouse models for AD, intraperitoneal injection of the TSPO...
...TSPO ligand, PK-11195, significantly decreased Ab40 levels compared with vehicle (p<0.001). Ongoing efforts include evaluating TSPO...
BioCentury | Apr 29, 2013
Strategy

Zerhouni's progress report

...Ph II Discontinued Nerispirdine (HP184) Potassium/sodium channel blocker Multiple sclerosis (MS) Ph II Discontinued SSR180575 Peripheral benzodiazepine receptor...
BioCentury | Nov 7, 2011
Clinical News

TRO40303: Phase II started

...Marseille, France Product: TRO40303 Business: Cardiovascular Molecular target: Peripheral benzodiazepine receptor (TSPO) (PBR) Description: Peripheral benzodiazepine receptor (TSPO; PBR...
BioCentury | Mar 7, 2011
Clinical News

TRO40303: Phase I data

...Marseille, France Product: TRO40303 Business: Cardiovascular Molecular target: Peripheral benzodiazepine receptor (TSPO) (PBR) Description: Peripheral benzodiazepine receptor (TSPO; PBR...
BioCentury | Oct 11, 2010
Clinical News

TRO40303: Phase I started

...Marseille, France Product: TRO40303 Business: Cardiovascular Molecular target: Peripheral benzodiazepine receptor (TSPO) (PBR) Description: Peripheral benzodiazepine receptor (TSPO; PBR...
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