BC Innovations | Oct 18, 2018
Distillery Therapeutics


INDICATION: Ovarian cancer Patient sample and mouse studies suggest T cell-specific inhibition of XBP1 or IRE1 could help treat ovarian cancer. In tumor and ascites samples from patients, high T cell expression of XBP1 was...
BC Extra | Oct 27, 2017
Preclinical News

Cell study points to new antibiotic strategy

A study in Cell shows granzyme B (GrB; GZMB), an immune cell protease, kills diverse bacterial species by shutting down multiple conserved survival pathways. The authors suggest compounds that mimic the protease’s mechanism could treat...
BC Innovations | Oct 29, 2015
Translation in Brief

Tumor turncoat

Instead of engineering T cells to kill tumors, researchers at The Scripps Research Institute have found a way to direct a patient's own leukemia cells to kill each other by using an agonist antibody that...
BC Innovations | Oct 8, 2015
Translation in Brief

Perforin stance

A recently identified subclass of dendritic cells could link inflammation with metabolic syndrome and autoimmunity, and might represent an alternative target to T regulatory cells for controlling inflammation. The cells, dubbed perf-DCs, express perforin 1...
BC Innovations | Feb 13, 2014
Tools & Techniques

Micromanaging the microenvironment

A Massachusetts team has designed an in vivo shRNA screen to discover immunosuppressive tumor targets that can be blocked to improve the efficacy of T cell immunotherapies. 1 The screening system shows that current checkpoint...
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