BioCentury | Mar 13, 2019
Distillery Therapeutics

A PYY-IgG conjugate for obesity

...a PYY-IgG conjugate could help treat obesity. The fusion protein consists of a 33-amino acid PYY...
...also has PYY 1875 (NN9775), a PYY analog, in Phase I testing for obesity. TARGET/MARKER/PATHWAY: Peptide tyrosine-tyrosine (PYY)...
...e-mail: srangwal@its.jnj.com CONTACT: James N. Leonard, same affiliation as above e-mail: jleonar7@its.jnj.com Hongjiang Li liraglutide (NN9211) Janssen Glucagon-like peptide-1 (GLP-1) Peptide tyrosine-tyrosine (PYY) Obesity...
BioCentury | Dec 8, 2018
Strategy

Novo gets serious about AI-guided drug design

...agonist of GLP-1, glucagon (GCG) and gastric inhibitory protein (GIP); and two molecules targeting appetite-regulating peptide tyrosine-tyrosine (PYY)...
...high-dose Ozempic and these very interesting combinations, either with amylin, with GIP or with PYY [peptide tyrosine-tyrosine]...
BioCentury | Sep 21, 2017
Targets & Mechanisms

Appetite for GFRAL

...analogs of one or more of the following molecules: amylin, FGF21 , glucagon , GLP-1, PYY...
...receptor 142 MAPK (ERK) - MAP kinase MOR (OPRM1) - μ opioid receptor PYY - Peptide tyrosine-tyrosine...
BioCentury | Jul 13, 2017
Translation in Brief

Mind over matter

...the CNS and the peripheral enteric system. A range of targets have been identified, including peptide tyrosine-tyrosine (PYY)...
BioCentury | Mar 25, 2017
Strategy

Mountain climbing

...I programs include the once-weekly basal insulin analog LAI287, the liver-preferential insulin analog PI406, and PYY...
...analog AM833, glucagon analog G530S, a co-agonist of glucagon and GLP-1, an FGF21 analog and PYY...
BioCentury | Jan 9, 2014
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...and contact information Endocrine/metabolic disease Obesity Neuropeptide Y receptor Y2 (NPY2R); peptide tyrosine-tyrosine (PYY) Mouse studies suggest PYY...
...delivered as an oral spray could help suppress appetite and treat obesity. Systemic delivery of PYY...
...delivery of PYY caused taste aversion, whereas an oral spray did not. The orally delivered PYY...
BioCentury | Jan 16, 2012
Clinical News

LX4211 tablet: Phase I data

...1 (GLP-1) vs. either treatment alone (p<0.001). LX4211 plus Januvia also increased total GLP-1 (p<0.001), PYY...
...Change in baseline in fasting plasma glucose (FPG), postprandial glucose (PPG), insulin, peptide YY ( PYY...
BioCentury | Sep 26, 2011
Clinical News

EndoBarrier Gastrointestinal Liner endocrine/metabolic data

...excess mean weight loss of 29.8%. EndoBarrier also significantly improved fasting glucose and significantly increased PYY...
...II diabetes Endpoint: Change from baseline in HbA1c, insulin, glucagon-like peptide-1 (GLP-1) and peptide YY (PYY...
BioCentury | Feb 7, 2011
Product Development

Obesity Reset

...molecule inhibitor of agouti related protein (AGRP) Ph II Emisphere Technologies Inc. (OTCBB:EMIS) GLP-1 plus PYY(3-36...
BioCentury | Jan 10, 2011
Finance

Highlights of weekly biotech stock moves

...solid oral LX4211 significantly improved total glucagon-like peptide-1 (GLP-1) , active GLP-1 and peptide YY (PYY...
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