BioCentury | Sep 12, 2019
Distillery Therapeutics

CDK11B as a new cancer target

...cancers including colorectal, pancreatic, lung cancer and melanoma. In colorectal cancer cells, the PDZ binding kinase (TOPK; PBK...
BioCentury | Sep 11, 2019
Translation in Brief

Cold Spring Harbor team finds off-target activity can drive antitumor effects

...colorectal cancers. In CRISPR-based assays to clarify the mechanism of one of the compounds, preclinical TOPK...
...Targets: CDK11B - Cyclin dependent kinase 11B; HDAC6 - Histone deacetylase 6; TOPK (PBK) - PDZ binding kinase Sandi...
BioCentury | Jan 5, 2015
Finance

4Q14 Stock Wrap-up: Grow early, grow often

...Science Inc. rose 252% after publication of preclinical data for its PDZ binding kinase ( TOPK ; PBK...
...T cells for ALL ." The Lancet (Oct. 12, 2014) Matsuo, Y., et al. " TOPK...
BioCentury | Nov 20, 2014
Cover Story

Tapping TOPK

...cells, several companies are still exploring enzymes that could be tractable targets.A new inhibitor of TOPK-an...
...the potential for hematopoietic toxicity would not pose a significant risk. TOPK ( PDZ binding kinase ; PBK...
...of TOPK-expressing cancer cell lines with low nanomolar IC 50 values and high selectivity for TOPK...
BioCentury | Nov 13, 2014
Distillery Therapeutics

Indication: Cancer

...contact information Cancer Breast cancer; lung cancer PDZ binding kinase (PBK; TOPK) Mouse studies suggest a selective TOPK...
...TOPK expression correlated with a poor prognosis. In a mouse model of TOPK-expressing cancer, a TOPK-selective...
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