...42 patients with advanced pancreatic cancer and a pathogenic germline or somatic BRCA1, BRCA2 or PALB2...
...Breast cancer 1 early onset; BRCA2 - Breast cancer 2 early onset; PALB2 - Partner and localizer of BRCA2...

...one inactivating mutation in a DDR gene, including BRCA1/2, ATM, Fanconi anemia genes, Chk2 and PALB2...
...BRCA2 - Breast cancer 2 early onset Chk2 (CHEK2) - Chekpoint kinase 2 PALB2 - Partner and localizer of BRCA2 Erin...

...No. 1348 ). In addition, a group from University of Bologna demonstrates the BRCA2 cofactor PALB2...
...NKG2C (KLRC2) - Killer cell lectin like receptor 2 Notch 1 - NOTCH1 PALB2 - Partner and localizer of BRCA2...

...the frequency of mutations or alterations in 276 DNA damage repair genes, including PARP-1, partner and localizer of BRCA2 (PALB2...

...DNA repair defects, as assessed by mutations in BRCA1, BRCA2, ATM, PTEN, CHEK2, RAD51C, RAD51D, PALB2...
...protein Msh2 MSH6 - mutS homolog 6 (MSH6) OGT - O-linked N-acetylglucosamine transferase PALB2 - Partner and localizer of BRCA2...
...HIF-PH2) (PHD2) Mdm2 p53 binding protein homolog (MDM2) (HDM2) mutS homolog 6 (MSH6) O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) Partner and localizer of BRCA2 (PALB2) Phosphatase...

...ataxia telangiectasia mutated (ATM), checkpoint kinase 2 ( Chk2 ; CHEK2 ), and partner and localizer of BRCA2 ( PALB2...

...CDH1 ; CD324 ), serine/threonine kinase 11 ( STK11 ; LKB1 ), and partner and localizer of BRCA2 (PALB2...

...cancer susceptibility genes, including the breast cancer 1 early onset (BRCA1) , BRCA2 and partner and localizer of BRCA2 (PALB2...

...Invitae launched PALB2 testing worldwide to diagnose cancer. The test includes full sequencing and deletion/duplication analysis...
...worldwide to diagnose cancer. The test includes full sequencing and deletion/duplication analysis of the partner and localizer of BRCA2 (PALB2...

...mouse model for Palb2-deficient breast cancer could be useful for evaluating new therapies. Mutations in PALB2...
...model, mice were engineered to carry Palb2 that could be conditionally inactivated. In this model, Palb2...
...tumor formation. Next steps could include using the mouse model to evaluate therapies to treat PALB2...