BioCentury | Apr 5, 2019
Clinical News

Clovis' PARP inhibitor leads to PFS of 9.1 months in pancreatic cancer

...42 patients with advanced pancreatic cancer and a pathogenic germline or somatic BRCA1, BRCA2 or PALB2...
...Breast cancer 1 early onset; BRCA2 - Breast cancer 2 early onset; PALB2 - Partner and localizer of BRCA2...
BioCentury | Mar 15, 2019
Product Development

Broadening the PARP playing field

...one inactivating mutation in a DDR gene, including BRCA1/2, ATM, Fanconi anemia genes, Chk2 and PALB2...
...BRCA2 - Breast cancer 2 early onset Chk2 (CHEK2) - Chekpoint kinase 2 PALB2 - Partner and localizer of BRCA2 Erin...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...No. 1348 ). In addition, a group from University of Bologna demonstrates the BRCA2 cofactor PALB2...
...NKG2C (KLRC2) - Killer cell lectin like receptor 2 Notch 1 - NOTCH1 PALB2 - Partner and localizer of BRCA2...
BioCentury | Apr 17, 2018
Distillery Techniques

Biomarkers

...the frequency of mutations or alterations in 276 DNA damage repair genes, including PARP-1, partner and localizer of BRCA2 (PALB2...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Meeting the burden

...DNA repair defects, as assessed by mutations in BRCA1, BRCA2, ATM, PTEN, CHEK2, RAD51C, RAD51D, PALB2...
...protein Msh2 MSH6 - mutS homolog 6 (MSH6) OGT - O-linked N-acetylglucosamine transferase PALB2 - Partner and localizer of BRCA2...
...HIF-PH2) (PHD2) Mdm2 p53 binding protein homolog (MDM2) (HDM2) mutS homolog 6 (MSH6) O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) Partner and localizer of BRCA2 (PALB2) Phosphatase...
BioCentury | Oct 29, 2015
Clinical News

AZ's olaparib leads to responses in CRPC

...ataxia telangiectasia mutated (ATM), checkpoint kinase 2 ( Chk2 ; CHEK2 ), and partner and localizer of BRCA2 ( PALB2...
BioCentury | Nov 17, 2014
Company News

Quest Diagnostics sales and marketing update

...CDH1 ; CD324 ), serine/threonine kinase 11 ( STK11 ; LKB1 ), and partner and localizer of BRCA2 (PALB2...
BioCentury | Oct 20, 2014
Company News

Pathway Genomics sales and marketing update

...cancer susceptibility genes, including the breast cancer 1 early onset (BRCA1) , BRCA2 and partner and localizer of BRCA2 (PALB2...
BioCentury | Sep 1, 2014
Company News

Invitae sales and marketing update

...Invitae launched PALB2 testing worldwide to diagnose cancer. The test includes full sequencing and deletion/duplication analysis...
...worldwide to diagnose cancer. The test includes full sequencing and deletion/duplication analysis of the partner and localizer of BRCA2 (PALB2...
BioCentury | Jun 6, 2013
Distillery Techniques

Technology: Disease models

...mouse model for Palb2-deficient breast cancer could be useful for evaluating new therapies. Mutations in PALB2...
...model, mice were engineered to carry Palb2 that could be conditionally inactivated. In this model, Palb2...
...tumor formation. Next steps could include using the mouse model to evaluate therapies to treat PALB2...
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