BioCentury | Sep 6, 2018
Preclinical News

Salk team reports gene therapy can re-grow skin in cutaneous ulcers

Researchers from Salk Institute for Biological Studies and colleagues developed a gene therapy delivering four transcription factors to regenerate epithelial cells from wound-resident mesenchymal cells in cutaneous ulcers. By delivering reprogramming factors directly to a...
BioCentury | Aug 29, 2018
Translation in Brief

Accelerated healing

In a Science Translational Medicine paper published last month, an NIH team showed SRY (sex determining region Y)-box 2 (SOX2) and paired-like homeodomain 1 (PITX1) can activate wound healing, and is now evaluating the transcription...
BioCentury | Sep 14, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: August 2017

...help treat AD. University of Kansas; University of South Florida Preclinical News Parkinson’s disease; neurology Paired like homeodomain 3 (PITX3)...
...somatic cells into dopaminergic neurons with the combination of electromagnetized nanoparticles and lentiviral vectors encoding PITX3...
BioCentury | Aug 16, 2017
Distillery Therapeutics

Neurology

...involves lentiviral vectors encoding the dopaminergic neuron transcription factors ASCL1 , LMX1A , NURR1 and PITX3...
...factor 1 α (LMX1A; LMX1); nuclear receptor subfamily 4 group A member 2 (NURR1; NR4A2); paired like homeodomain 3 (PITX3)...
...homeobox transcription factor 1 alpha (LMX1A) (LMX1) Nuclear receptor subfamily 4 group A member 2 (NURR1) (NR4A2) Paired like homeodomain 3 (PITX3)...
BioCentury | Jan 7, 2016
Distillery Techniques

Techniques: Five-gene CpG methylation signature to predict outcomes in clear cell renal cell carcinoma (ccRCC) patients

Biomarkers EH domain binding protein 1-like 1 (EHBP1L1) forkhead box E3 (FOXE3) paired-like homeodomain 1 (PITX1) Ras and RAB interactor 1 (RIN1) twinfilin actin binding protein 2 (TWF2) Sun Yat-sen University BC Staff...
BioCentury | Aug 15, 2011
Company News

Epigenomics genomics, diagnostic news

Epigenomics will restructure and reduce headcount by about 39 (46%) to 45 and will discontinue early stage research to focus on the U.S. market. Details on the cuts were not disclosed. Epigenomics said it is...
BioCentury | May 27, 2010
Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Fibrillation; tachycardia Paired-like homeodomain transcription factor 2 (PITX2); short stature homeobox 2 (SHOX2) Studies in mice and in vitro suggest that PITX2 agonists or...
BioCentury | Jun 22, 2009
Clinical News

PC-MCT: Pivotal trial additional data

Additional data from an analysis of tissue samples taken from 476 patients with prostate cancer showed that biochemical recurrence-free survival at 5 years post-prostatectomy was 85% and 61% for patients with low and high respective...
BioCentury | Oct 20, 2008
Clinical News

PC-MCT: Pivotal trial data

Analysis of tissue samples taken from 476 patients with prostate cancer showed that those with elevated paired-like homeodomain transcription factor 2 (PITX2) gene methylation levels had a 3-fold higher risk of relapse following prostatectomy compared...
BioCentury | Apr 10, 2006
Clinical News

Epigenomics preclinical data

Data from tumor tissues taken from prostate cancer patients showed that those who tested positive for methylation of paired-like homeodomain transcription factor 2 gene ( PITX2 ) were 3 times more likely to experience cancer recurrence. PITX2...
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