15:30 , Jul 25, 2018 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts Zebrafish expressing human PAX3 and FOXO1 could be used to screen therapies for rhabdomyosarcoma. Zebrafish harboring M214K-mutant p53, engineered to express human PAX3 and FOXO1 and injected with a ubiquitous promoter developed...
21:40 , Jul 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Sarcoma Cell culture and mouse studies suggest combining Mekinist trametinib with IGF1R inhibitors could help treat PAX3-PAX7 fusion-negative rhabdomyosarcoma. Screening of a panel of 1,912 approved or tool compound small molecule inhibitors in a viability...
23:36 , Apr 10, 2018 |  BC Extra  |  Preclinical News

Researchers identify coding, non-coding driver mutations in MM

Scientists from the Institute of Cancer Research (London, U.K.) identified coding and non-coding driver mutations involved in newly diagnosed multiple myeloma, suggesting the genes could be targeted to treat the disease. The research was published...
19:06 , Dec 22, 2016 |  BC Innovations  |  Translation in Brief

Pin the tail

Stanford University researchers have provided preclinical proof of concept that adding polyadenine (polyA) tails to atypical sites on mRNAs could treat disease. Although the team applied the strategy to the transcript of the fibrosis target,...
19:37 , Dec 6, 2016 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Sarcoma Cell culture studies suggest inhibiting CHD4 could help treat PAX-FOX1 fusion gene-positive rhabdomyosarcomas. In two human rhabdomyosarcoma cell lines positive for the PAX-FOX1 fusion oncogene, shRNA targeting CHD4 decreased cell numbers and colony numbers...
07:00 , Jun 16, 2016 |  BC Innovations  |  Emerging Company Profile

No cells left behind

Although transplantation of human islets from donated pancreatic tissue is well known to restore insulin production in Type I diabetes patients, there is a severe shortage of donor tissue. Islexa Ltd. has developed a way...
07:00 , Apr 14, 2016 |  BC Innovations  |  Product R&D

AACR by the numbers

See Figure: Top indications See Table: Novel cancer targets at AACR 2016 See Figure: Top institutions and companies See Figure: Top targets Tables Novel cancer targets at...
08:00 , Dec 14, 2015 |  BioCentury  |  Product Development

Following CoMMpass

Amidst a flood of promising data for hot targets, indications and technologies at this year's American Society of Hematology meeting, one collection of presentations stands out not only for the wide-reaching implications of their data,...
07:00 , Jul 16, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: SNPs on paired box gene 8 (PAX8) and homeobox D9 (HOXD9) as risk markers for mucinous ovarian carcinoma

BiomarkersPAX8HOXD9paired box gene 8 (PAX8)homeobox D9 (HOXD9)University of Southern California...
07:00 , Sep 25, 2014 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Cultured human muscle satellite cells to restore gene function in muscular dystrophies Cell culture and mouse studies suggest cultured...