BioCentury | Oct 21, 2019
Emerging Company Profile

Verseau unveils tumor macrophage reprogramming strategy

...a collaboration with 3SBio Inc. (HKSE:1530), Verseau Therapeutics Inc. unveiled its first macrophage checkpoint program, anti-PSGL-1...
...None issued Targets PD-1 (PDCD1; CD279) - Programmed cell death 1 PSGL-1 (CD162; SELPLG) - P selectin glycoprotein ligand-1...
...regulatory protein alpha STAB1 (CLEVER-1; FEEL-1) - Stabilin 1 Sandi Wong, Staff Writer Verseau Therapeutics Inc. P selectin glycoprotein ligand-1 (PSGL-1) (CD162...
BioCentury | Jul 6, 2018
Emerging Company Profile

Tethering bleeding risk

...was responsible for discovery and development of hematology drug Soliris eculizumab. SelK2 inhibits P selectin glycoprotein ligand-1 (PSGL-1; CD162...
...SELL). The mechanism inhibits thrombosis initiated by SELP-expressing platelets and endothelial cells and also blocks PSGL-1...
...BCIQ database, at least one other company, AbGenomics Holding Ltd., has a clinical program targeting PSGL-1...
BioCentury | Apr 20, 2018
Financial News

Tetherex raises $50M series B, plans Phase II for pan-selectin inhibitor

...II," Rollins said. Tetherex and its SelK2 program -- a humanized mAb against P selectin glycoprotein ligand-1 (PSGL-1; CD162...
...the product in 2019. Rollins said that SelK2 affects broader targets than crizanlizumab because the anti-PSGL-1...
...Oklahoma City, Okla. Jennie Walters crizanlizumab (SEG101, selg1) SelK2 Novartis AG Selexys Pharmaceuticals Corp. Tetherex Pharmaceuticals Inc. P selectin (SELP) (CD62P) P selectin glycoprotein ligand-1 (PSGL-1) (CD162...
BioCentury | Apr 18, 2018
Financial News

Tetherex raises $50M series B, plans Phase II for pan-selectin inhibitor

...II," Rollins said. Tetherex and its SelK2 program -- a humanized mAb against P selectin glycoprotein ligand-1 (PSGL-1; CD162...
...the product in 2019. Rollins said that SelK2 affects broader targets than crizanlizumab because the anti-PSGL-1...
...2014 through the sale of convertible notes. Jennie Walters Novartis AG Selexys Pharmaceuticals Corp. P selectin (SELP) (CD62P) P selectin glycoprotein ligand-1 (PSGL-1) (CD162...
BioCentury | Jun 23, 2016
Distillery Therapeutics

Therapeutics: P selectin glycoprotein ligand-1 (PSGL-1; CD162; SELPLG)

...Infectious disease INDICATION: Viral infection; melanoma Mouse studies suggest PSGL-1 inhibitors could help treat chronic viral...
...inflammatory cytokines compared with normal PSGL-1 expression. In a mouse model of melanoma, knockout of PSGL-1...
...T cells. Next steps could include identifying small molecule inhibitors of PSGL-1. TARGET/MARKER/PATHWAY: P selectin glycoprotein ligand-1 (PSGL-1; CD162...
BioCentury | Oct 29, 2015
Emerging Company Profile

Rebuilding the barrier

...adhesion molecules, and antibodies against VCAM-1 or SELP on endothelial cells, or integrin α4 or PSGL-1...
...and Compounds Integrin α4 ( VLA-4 ; CD49D ) PSGL-1 ( CD162 ; SELPLG) - P selectin glycoprotein ligand-1...
BioCentury | Apr 16, 2015
Product R&D

Antagonizing psoriasis

...LFA-1 (CD11a-CD18) , lymphocyte-activation gene 3 ( LAG3 ; CD223 ), P selectin glycoprotein ligand-1 ( PSGL-1 ; CD162...
BioCentury | Oct 10, 2013
Distillery Techniques

Technology: Drug platforms

...mesenchymal stem cells (MSCs) overexpressing P selectin glycoprotein ligand-1 (PSGL-1; CD162; SELPLG), Sialyl-LewisX (SLeX) and IL-10 MSCs overexpressing PSGL-1...
...to treat inflammation. In mice with lipopolysaccharide (LPS)-induced ear inflammation, retro-orbitally injected MSCs transfected with Psgl-1...
...the inflamed endothelium than unmodified MSCs. In the same model, systemically injected MSCs transfected with Psgl-1...
BioCentury | Sep 24, 2012
Finance

Selexys' sickle sale

...biotech would spin out its other asset, a preclinical antibody against P selectin glycoprotein ligand-1 ( PSGL-1 ; CD162...
BioCentury | Feb 6, 2012
Company News

AbGenomics, Boehringer Ingelheim deal

...exclusive, worldwide rights to develop and commercialize the humanized mAb against P selectin glycoprotein ligand-1 ( PSGL-1 ; CD162...
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