BioCentury | Nov 1, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: October 2017

New Therapeutic Targets and Biomarkers: October 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during October 2017. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Oct 31, 2017
Distillery Therapeutics

Infectious disease

INDICATION: Malaria Cell culture studies suggest inhibiting P. falciparum plasmepsin IX and P. falciparum plasmepsin X could help treat malaria. In P. falciparum -infected human erythrocytes, knockout of plasmepsin IX decreased parasite expansion and invasion,...
BioCentury | Jan 7, 2016
Distillery Therapeutics

Therapeutics: P. falciparum plasmepsin I; P. falciparum plasmepsin II; P. falciparum plasmepsin IV

...2,000 μM. Next steps could include testing the compounds in animal models of malaria. TARGET/MARKER/PATHWAY: P. falciparum plasmepsin I...
BioCentury | Feb 18, 2010
Distillery Therapeutics

Indication: Indication

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum plasmepsin V (PMV; PF13_0133) Cell culture studies suggest that inhibiting PMV could help treat malaria infection. In vitro assays showed that...
BioCentury | Oct 15, 2009
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmepsin (Plasmodium falciparum) In vitro studies identified a plasmepsin inhibitor that could aid in the development of new treatments for malaria. An affinity-based...
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