07:00 , Oct 6, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: P. falciparum phenylalanyl-tRNA synthetase

Infectious disease INDICATION: Malaria In vitro and mouse studies identified a bicyclic azetidine-based inhibitor of Plasmodium falciparum phenylalanine-tRNA synthetase that could help treat malaria. Screening of a small molecule library in a cell-based assay followed by optimization...
07:00 , Sep 29, 2016 |  BC Innovations  |  Targets & Mechanisms

Hitting for the cycle

Driven by the need for antimalarial drugs that hit all stages of the life cycle of the malaria parasite, a group at the Broad Institute of MIT and Harvard has constructed and screened a diverse...