BioCentury | Jul 19, 2012
Distillery Therapeutics

Indication: Infectious disease

...disease Malaria Plasmodium falciparum lysyl-tRNA synthetase (Pfkrs1) In vitro and cell culture studies suggest inhibiting Pfkrs1...
...the gene is the direct target of cladosporin. In an in vitro assay, cladosporin inhibited Pfkrs1...
...high micromolar concentrations for the human homolog. Next steps could include screening for more drug-like Pfkrs1...
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