BioCentury | Jun 2, 2016
Distillery Therapeutics

Therapeutics: P. falciparum dihydroorotate dehydrogenase (PfDHODH); P. vivax dihydroorotate dehydrogenase (PvDHODH)

...Infectious disease INDICATION: Malaria In vitro and mouse studies identified triazolopyrimidine-based inhibitors of PfDHODH and PvDHODH...
...Chemical synthesis and in vitro testing of triazolopyrimidine analogs identified three compounds that bound to PfDHODH...
...Next steps could include optimizing and testing the compounds in models of malaria infection. TARGET/MARKER/PATHWAY: P. falciparum dihydroorotate dehydrogenase (PfDHODH)...
BioCentury | Oct 31, 2013
Distillery Therapeutics

Indication: Infectious disease

...Malaria Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) Mouse and in vitro studies identified dihydrothiophenone-derived inhibitors of PfDHODH...
...that could be useful for treating malaria. In in vitro assays, the lead compound inhibited PfDHODH...
BioCentury | Jun 9, 2011
Distillery Therapeutics

Indication: Infectious disease

...pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH...
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