07:00 , Jun 2, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: P. falciparum dihydroorotate dehydrogenase (PfDHODH); P. vivax dihydroorotate dehydrogenase (PvDHODH)

Infectious disease INDICATION: Malaria In vitro and mouse studies identified triazolopyrimidine-based inhibitors of PfDHODH and PvDHODH that could help treat malaria. Chemical synthesis and in vitro testing of triazolopyrimidine analogs identified three compounds that bound to PfDHODH...
07:00 , Oct 31, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) Mouse and in vitro studies identified dihydrothiophenone-derived inhibitors of PfDHODH...
07:00 , Jun 9, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) In vitro and rodent...