BC Innovations | Jun 2, 2016
Distillery Therapeutics

Therapeutics: P. falciparum dihydroorotate dehydrogenase (PfDHODH); P. vivax dihydroorotate dehydrogenase (PvDHODH)

Infectious disease INDICATION: Malaria In vitro and mouse studies identified triazolopyrimidine-based inhibitors of PfDHODH and PvDHODH that could help treat malaria. Chemical synthesis and in vitro testing of triazolopyrimidine analogs identified three compounds that bound...
BC Innovations | Oct 31, 2013
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) Mouse and in vitro studies identified dihydrothiophenone-derived inhibitors of PfDHODH that could be useful for treating malaria. In...
BC Innovations | Jun 9, 2011
Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) In vitro and rodent studies identified improved analogs of DHODH inhibitors that could...
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