BioCentury | Apr 25, 2020
Translation in Brief

Molecular Partners’ trifunctional COVID-19 therapeutic; plus F-star, Inscopix and Ocean Biomedical

...Better Preclinical Models" ). New malaria vaccine target Ocean Biomedical Inc. showed that vaccines delivering P. falciparum...
...Nature , comparison of antigens recognized by antibodies children resistant vs. susceptible to malaria identified P. falciparum...
...of infected red blood cells. In infected monkeys, prior immunization with recombinant protein or mRNA-encoded P. falciparum...
BioCentury | Aug 1, 2019
Distillery Therapeutics

Enhancing malaria prevention with a non-neutralizing mAb

...DISEASE CATEGORY: Infectious disease INDICATION: Malaria A non-neutralizing mAb against P. falciparum Rh5, which mediates red blood...
...antibodies against the antigen or other malarial proteins. A parasite growth inhibition screen of anti- P. falciparum...
...identified a non-neutralizing mAb that enhanced growth inhibition of eight neutralizing mAbs, polyclonal antibodies against P. falciparum...
BioCentury | May 8, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: April 2019

...Therapeutics Inc. ; Schrödinger LLC Emerging Company Profile Malaria; Cryptosporidium Plasmodium falciparum lysine-tRNA ligase ( P. falciparum...
...ligase) In vitro , cell culture and mouse studies identified a chromene carboxamide-based inhibitor of P. falciparum...
BioCentury | Apr 23, 2019
Company News

Pilot program for GSK's malaria vaccine starts in Malawi

WHO launched a planned pilot program of GSK's malaria vaccine RTS,S in Malawi on Tuesday with the goal of informing the organization's policy recommendations for broader use of the vaccine. The organization will also roll...
BioCentury | Apr 2, 2019
Distillery Therapeutics

Microbial lysine-tRNA ligase inhibitor for malaria and Cryptosporidium

...Cryptosporidium In vitro , cell culture and mouse studies identified a chromene carboxamide-based inhibitor of P. falciparum...
...compounds, followed by optimization of the top hit, yielded a chromene carboxamide-based compound that inhibited P. falciparum...
...parvum lysine-tRNA ligases with IC 50 values of 0.015 and 0.13 μM, respectively. In three P. falciparum...
BioCentury | Feb 20, 2019
Distillery Therapeutics

Infectious disease

...and mefloquine - with IC 50 values below 46 nM. In blood samples from 10 P. falciparum...
BioCentury | Feb 14, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: January 2019

...disease Malaria Plasmodium falciparum serine/threonine protein kinase (P. falciparum PK9) In vitro and cell culture studies identified two P. falciparum PK9...
...17 (P. falciparum PSSP17; PF3D7_1218800)  An assay for detecting P. falciparum PSSP17 in saliva could help rapidly diagnose clinical and subclinical P. falciparum infection...
BioCentury | Jan 23, 2019
Distillery Techniques

Assays and screens

...An assay for detecting P. falciparum PSSP17 in saliva could help rapidly diagnose clinical and subclinical P. falciparum...
...line, which indicates P. falciparum infection. When applied to saliva samples from 100 children with subclinical P. falciparum...
...falciparum sexual stage protein 17 ( P. falciparum PSSP17; PF3D7_1218800) in saliva for rapid diagnosis of P. falciparum...
BioCentury | Jan 8, 2019
Distillery Therapeutics

Infectious disease

...INDICATION: Malaria In vitro and cell culture studies identified two P. falciparum PK9 inhibitors that could help...
...that could help treat malaria. Screening of a kinase inhibitor library in HEK cells expressing P. falciparum...
...Rose Derbyshire, Duke University, Durham, N.C. email: emily.derbyshire@duke.edu Claire Quang Duke University Plasmodium falciparum serine/threonine protein kinase (P. falciparum PK9) Malaria P. falciparum...
BioCentury | Sep 13, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: August 2018

...P. falciparum proteasome subunit β type 2 that could help treat malaria Stanford University Distillery Therapeutics P. falciparum...
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