BC Innovations | Aug 1, 2019
Distillery Therapeutics

Enhancing malaria prevention with a non-neutralizing mAb

DISEASE CATEGORY: Infectious disease INDICATION: Malaria A non-neutralizing mAb against P. falciparum Rh5, which mediates red blood cell invasion, could improve the efficacy of vaccines based on neutralizing antibodies against the antigen or other malarial...
BC Innovations | May 8, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: April 2019

New Therapeutic Targets and Biomarkers: April 2019 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during April. Therapeutic targets are defined as any protein, gene or other molecule...
BC Innovations | Apr 2, 2019
Distillery Therapeutics

Microbial lysine-tRNA ligase inhibitor for malaria and Cryptosporidium

DISEASE CATEGORY: Infectious disease INDICATION: Malaria; Cryptosporidium In vitro , cell culture and mouse studies identified a chromene carboxamide-based inhibitor of P. falciparum lysine-tRNA ligase and Cryptosporidium lysine-tRNA ligase that could help treat malaria and Cryptosporidium...
BC Innovations | Feb 20, 2019
Distillery Therapeutics

Infectious disease

INDICATION: Malaria Cell culture, patient sample and mouse studies identified a bitriazine-based compound that could help treat malaria. Chemical synthesis and testing of bitriazine analogs in human erythrocyte-based assays of Plasmodium falciparum growth identified a...
BC Innovations | Feb 14, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: January 2019

New Therapeutic Targets and Biomarkers: January 2019 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during January. Therapeutic targets are defined as any protein, gene or other molecule...
BC Innovations | Jan 23, 2019
Distillery Techniques

Assays and screens

TECHNOLOGY: Diagnostic assays An assay for detecting P. falciparum PSSP17 in saliva could help rapidly diagnose clinical and subclinical P. falciparum infection at the point of care. The assay comprises mixing saliva samples with two...
BC Innovations | Jan 8, 2019
Distillery Therapeutics

Infectious disease

INDICATION: Malaria In vitro and cell culture studies identified two P. falciparum PK9 inhibitors that could help treat malaria. Screening of a kinase inhibitor library in HEK cells expressing P. falciparum PK9, in vitro binding...
BC Innovations | Sep 13, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: August 2018

New Therapeutic Targets and Biomarkers: August 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in August 2018. Therapeutic targets are defined as any protein, gene or other...
BC Innovations | Aug 29, 2018
Distillery Therapeutics

Infectious disease

INDICATION: Malaria In vitro , cell culture and mouse studies identified asparagine ethylenediamine-based inhibitors of Plasmodium falciparum proteasome subunit β type 5 that could help treat malarial infection. Screening of a library of tool compound proteasome...
BC Innovations | Aug 23, 2018
Distillery Therapeutics

Infectious disease

INDICATION: Malaria Cell culture and mouse studies identified an inhibitor of P. falciparum proteasome subunit β type 2 and proteasome subunit β type 5 that could help treat malaria. Chemical synthesis and testing of vinyl...
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