00:11 , Jun 4, 2019 |  BC Innovations  |  Distillery Therapeutics

RELMα and RETN for Gram-positive and Gram-negative bacterial infections

DISEASE CATEGORY: Infectious disease INDICATION: Gram-positive bacterial infection; Gram-negative bacterial infection; Pseudomonas; Streptococcus Bacterial culture studies suggest RELMα and RETN could help treat Gram-positive and other bacterial infections. In cultures of Gram-positive Streptococcus pyogenes and...
11:54 , Apr 18, 2019 |  BC Innovations  |  Translation in Brief

Blocking phages to prevent wound infections

Stanford researchers have shown that immunizing against a bacteriophage found in Pseudomonas aeruginosa prevented the bacteria from infecting chronic wounds. The findings offering a prophylactic alternative to using antibiotics to treat surgical and other wounds...
19:24 , Apr 15, 2019 |  BC Innovations  |  Distillery Therapeutics

MedImmune's bispecific mAb for Pseudomonas-related ocular keratitis

DISEASE CATEGORY: Infectious disease INDICATION: Pseudomonas Mouse studies suggest MEDI3902, a bispecific mAb against P. aeruginosa Psl and PcrV, could help treat ocular keratitis caused by P. aeruginosa infection. In a mouse model of bacterial...
19:24 , Apr 15, 2019 |  BC Innovations  |  Distillery Therapeutics

Targeting a Pseudomonas phage protein to prevent chronic wounds

DISEASE CATEGORY: Infectious disease INDICATION: Pseudomonas Patient sample and mouse studies suggest inhibiting or immunizing against Pf4 coaB could help prevent Pseudomonas aeruginosa infections in chronic wounds. In patients with chronic wounds infected by P....
13:52 , Apr 10, 2019 |  BC Innovations  |  Distillery Techniques

Method for generating CPS-based glycoconjugates for pneumococcal vaccines

TECHNIQUES CATEGORY: Drug platforms TECHNOLOGY: Conjugates An E. coli -based method for generating S. pneumoniae CPS-based glycoconjugates could be used to produce pneumococcal vaccines. Generation of the glycoconjugates involves expressing three factors in E. coli...
01:44 , Feb 21, 2019 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Multiple myeloma (MM) Studies in mice characterized two immunotoxins that could help treat BCMA-expressing MM. The immunotoxins consist of the cytotoxic Pseudomonas aeruginosa exotoxin domain III linked to a BCMA-targeting Fab fragment or variable...
20:06 , Dec 19, 2018 |  BC Innovations  |  Translation in Brief

Taking the sting out of AMPs

Massachusetts Institute of Technology researchers led by Timothy Lu have developed a rational-design method for engineering antimicrobial peptides from toxic molecules such as wasp venom, publishing their third approach to developing AMPs this year and...
20:03 , Dec 19, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Esherichia; Pseudomonas; Staphylococcus Mouse studies identified an analog of the wasp-derived peptide polybia-CP that could help treat E. coli , Pseudomonas and Staphylococcus infections. Chemical synthesis and screening in bacterial colony-based assays of polybia-CP...
23:25 , Oct 3, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Gram-negative bacterial infection In silico , in vitro and mouse studies identified an oxazolidinone-based LpxC inhibitor that could help treat Gram-negative bacterial infections. In silico screening of analogs of an indazole-based LpxC inhibitor, followed...
23:17 , Oct 3, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: September 2018

New Therapeutic Targets and Biomarkers: September 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in September. Therapeutic targets are defined as any protein, gene or other molecule...