01:44 , Feb 21, 2019 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Multiple myeloma (MM) Studies in mice characterized two immunotoxins that could help treat BCMA-expressing MM. The immunotoxins consist of the cytotoxic Pseudomonas aeruginosa exotoxin domain III linked to a BCMA-targeting Fab fragment or variable...
20:06 , Dec 19, 2018 |  BC Innovations  |  Translation in Brief

Taking the sting out of AMPs

Massachusetts Institute of Technology researchers led by Timothy Lu have developed a rational-design method for engineering antimicrobial peptides from toxic molecules such as wasp venom, publishing their third approach to developing AMPs this year and...
20:03 , Dec 19, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Esherichia; Pseudomonas; Staphylococcus Mouse studies identified an analog of the wasp-derived peptide polybia-CP that could help treat E. coli , Pseudomonas and Staphylococcus infections. Chemical synthesis and screening in bacterial colony-based assays of polybia-CP...
23:25 , Oct 3, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Gram-negative bacterial infection In silico , in vitro and mouse studies identified an oxazolidinone-based LpxC inhibitor that could help treat Gram-negative bacterial infections. In silico screening of analogs of an indazole-based LpxC inhibitor, followed...
23:17 , Oct 3, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: September 2018

New Therapeutic Targets and Biomarkers: September 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in September. Therapeutic targets are defined as any protein, gene or other molecule...
15:42 , Sep 27, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Bacterial infection In silico , cell culture and mouse studies identified a PGA3-derived antimicrobial peptide that could help treat bacterial infection. In silico screening of amino acid sequences of human secreted proteins for structural...
20:18 , Sep 26, 2018 |  BC Innovations  |  Translation in Brief

Digesting antimicrobial peptides

Synthetic biology researchers at Massachusetts Institute of Technology used a data-mining approach to identify a new antimicrobial peptide derived from a human digestive protein, adding a potential weapon in the battle against antibiotic resistance. As...
17:35 , Sep 26, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Pseudomonas Cell culture studies suggest inhibition of P. aeruginosa sodB or combined inhibition of P. aeruginosa relA and spoT could help treat chronic infections by the bacteria and prevent drug resistance. In stationary-phase P....
15:18 , Sep 20, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Gram-negative bacterial infection Mouse studies identified a member of the arylomycin class of bacterial lepB-inhibiting antibiotics that could help treat multidrug resistant (MDR) Gram-negative bacterial infections. Chemical synthesis and in vitro assays of arylomycin...
21:13 , Sep 12, 2018 |  BC Extra  |  Preclinical News

Genentech develops antibiotic against multidrug resistant Gram-negatives

Genentech Inc. researchers have developed arylomycin derivatives with potent activity against Gram-negative bacteria, including multidrug resistant (MDR) strains. The small molecule could represent a notable step forward against Gram-negative bacteria, for which no new class...