BioCentury | Mar 16, 2017
Targets & Mechanisms

Bone appétit!

...and release hormones. They are thought to play a role in metabolism because they secrete osteocalcin...
...hypothalamus to suppress appetite. Bone produces at least three proteins - LCN2 , FGF23 and osteocalcin...
...the mode of action is not clear (dashed green arrows) . Previous studies have shown osteocalcin...
BioCentury | Oct 13, 2016
Product R&D

Elastic bones

...the structure, grew to fill its volume, and expressed pro-osteogenic genes such as Opn , osteocalcin...
BioCentury | Oct 27, 2014
Clinical News

UX023: Extension study data

...increased biomarkers of bone formation and bone resorption, including procollagen type I N-propeptide (PINP) , osteocalcin...
BioCentury | Jul 14, 2014
Clinical News

UX023: Phase I/II data

...increased biomarkers of bone formation and bone resorption, including procollagen type I N-propeptide (PINP) , osteocalcin...
...baseline. The increase in PINP was significant after all doses (p<0.05) and the increase in osteocalcin...
BioCentury | Nov 5, 2012
Clinical News

Natpara: Additional Phase III data

...C-terminal telopeptide (CTX), 299 µg/L in procollagen type I N-propeptide (PINP) and 26 µg/L in osteocalcin...
BioCentury | Nov 5, 2012
Clinical News

Natpara: Phase III data

...week 8 in bone turnover markers C-terminal telopeptide (CTX), procollagen type I N-propeptide (PINP) and osteocalcin...
BioCentury | Jan 19, 2012
Cover Story

Spreadin' the news

...Francisco 2 and a three-year research collaboration with Columbia University to investigate the use of osteocalcin...
BioCentury | Nov 14, 2011
Clinical News

CCX354: Phase II data

...3 biomarkers of bone turnover - C-terminal telopeptide (CTX), procollagen type I N-propeptide (PINP) and osteocalcin...
BioCentury | Nov 3, 2011
Strategy

Hands-off incubator

...closed and that the company is "continuing to rethink its incubator strategy." Escoublac was developing osteocalcin...
BioCentury | Apr 14, 2011
Strategy

sanofi rolls the bones

...responsible for the hormone's metabolic effects and is internally devising strategies to develop osteocalcin or osteocalcin...
...hormone osteocalcin regulates glucose homeostasis in mice. 1 The researchers showed that animals treated with osteocalcin...
...blood glucose levels and greater insulin sensitivity than controls, 2 which suggested that osteocalcin or osteocalcin...
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