BioCentury | Jun 10, 2020
Emerging Company Profile

Autobahn: fine-tuning thyroid agonism to remyelinate axons

...adrenomyeloneuropathy (AMN). By activating thyroid hormone signaling, ABX-002 is intended to promote the differentiation of oligodendrocyte...
BioCentury | Apr 29, 2020
Emerging Company Profile

Taysha: Applying AAV9 across the CNS

Taysha launched with a $30 million seed round and a team of former AveXis leaders ready to parlay their experience with Zolgensma into a broad pipeline of AAV9-based gene therapies for other CNS disorders. The...
BioCentury | Feb 28, 2020
Distillery Therapeutics

Boosting OSM and TIMP1 levels to treat demyelinating diseases

...or its downstream mediator TIMP1 could treat demyelinating diseases such as MS. In cultures of oligodendrocyte...
BioCentury | Feb 1, 2020
Preclinical News

Cellular fluorescence assay to assess allosteric modulator potency in drug discovery

...a proof-of-concept experiment in HEK cells evaluating 10 compounds designed to allosterically disrupt dimerization of oligodendrocyte...
...least one company has approached them to test compounds using FCCS. Inhua Muijrers-Chen, Associate Editor Karolinska Institute Institut Pasteur UCSD Oligodendrocyte...
BioCentury | Sep 19, 2019
Product Development

Anokion puts liver to the test

...oligodendrocyte glycoprotein VLA-4 (CD49D) - Integrin alpha(4) Allison Johnson, Senior Writer Tysabri, natalizumab (AN100226, Antegren) Biogen Inc. Anokion S.A. Myelin oligodendrocyte...
BioCentury | May 14, 2019
Distillery Techniques

A mouse model to screen therapies for Williams syndrome

TECHNIQUES CATEGORY: Disease models TECHNOLOGY: Transgenics and knockouts GTF2I-deficient mice could be used to screen therapies for Williams syndrome, which is caused by gene deletions on chromosome 7 that lead to learning and cardiovascular problems....
BioCentury | May 7, 2019
Distillery Techniques

Expression of multigene panels in CNS cell types as markers of early AD

...levels of multigene panels in six CNS cell types -- excitatory neurons, inhibitory neurons, oligodendrocytes, oligodendrocyte...
BioCentury | May 6, 2019
Translation in Brief

Baby brain organoids link stress response to hypoxic encephalopathy

Brain organoids could help unravel one complication of extremely premature birth: hypoxic encephalopathy. A Stanford group used the technology to zero in on the unfolded protein response as a target for preventing the indication. Encephalopathy...
BioCentury | May 1, 2019
Translation in Brief

White matter matters in Alzheimer’s

...markers. The researchers also found differences based on sex, in particular more neuronal and fewer oligodendrocyte...
BioCentury | Apr 19, 2019
Targets & Mechanisms

The next wave in neurodegeneration expands beyond neurons

Working in the background, while amyloid therapies have floundered, has been a group of companies betting that the immune system can do for neurodegeneration what it is has done for oncology. The first wave of...
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