00:00 , Dec 12, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neurology Patient sample and mouse studies suggest depleting microglia with CSF1R inhibitors could help treat chemotherapy-induced neurological dysfunction. In postmortem frontal lobe tissue samples from pediatric and young adult patients treated with methotrexate and...
17:40 , Dec 11, 2018 |  BC Innovations  |  Translation in Brief

Diseased oligodendrocytes

A Karolinska Institute team has identified subsets of oligodendrocyte lineage cells that may trigger T cell immunity in multiple sclerosis and proposed the cells as new disease targets. The findings suggest the myelin-producing cells are...
17:33 , Sep 26, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neurology Mouse studies suggest antagonizing the muscarinic receptor CHRM1 could help treat white matter injury. In a mouse model of neonatal chronic hypoxia-induced white matter injury, CHRM1 knockout in oligodendrocyte precursor cells increased axon...
19:28 , Sep 10, 2018 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: 3-D models Patient-derived oligocortical spheroids could be used to study demyelinating diseases and screen therapies to treat them. The spheroids were generated by culturing human pluripotent stem cells with platelet derived growth factor AA...
01:46 , Aug 17, 2018 |  BC Innovations  |  Targets & Mechanisms

Unsaturated remyelination

Enzymes downstream in cholesterol biosynthesis could provide new ways to stimulate remyelination that avoid the baggage of previously identified multiple sclerosis targets, according to a group at Case Western. The university is spinning out Convelo...
23:49 , Aug 8, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neurology Mouse studies suggest CHRM3 antagonists could help treat demyelination diseases. In a mouse model of CNS demyelination, transplantation into the corpus callosum of CHRM3-deficient human oligodendrocyte progenitor cells (OPCs) increased the number of...
18:58 , May 9, 2018 |  BC Innovations  |  Translation in Brief

Dissecting rare gliomas

In an April Science study, researchers from Massachusetts General Hospital and Harvard Medical School identified a subpopulation of malignant cells driving disease progression in rare pediatric gliomas with mutated histone H3 K27M using single-cell RNA...
19:27 , Jan 4, 2018 |  BC Innovations  |  Translation in Brief

ArunA’s exosome entrance

Stem cell manufacturer ArunA Biomedical Inc. has announced a pivot into the exosome therapeutic space, as well as publication of the first data showing its neural stem cell-derived exosomes and other extracellular vesicles are effective...
23:50 , Dec 6, 2017 |  BC Extra  |  Preclinical News

BCAS1 could identify remyelinating cells

In a paper published in Science Translational Medicine , researchers at the Max Planck Institute for Experimental Medicine and their German colleagues show that breast cancer amplified sequence 1 (BCAS1) can be used a marker...
18:59 , Nov 3, 2017 |  BC Week In Review  |  Financial News

Asterias raises $10.4M in registered direct offering

On Oct. 19, Asterias Biotherapeutics Inc. (NYSE-M:AST) closed a registered direct offering led by Chardan, raising $10.4 million through the sale of 4 million shares at $2.60. The company said it will use the funds...