01:15 , Jan 25, 2019 |  BC Week In Review  |  Clinical News

Asterias' oligodendrocyte progenitor cell therapy improves motor function in SCI patients at 12 months

Asterias Biotherapeutics Inc. (NYSE-A:AST) reported 12-month data from the Phase I/IIa SCiStar trial to treat cervical spinal cord injury (SCI) showing that 21 of 22 patients (95%) who received 10 or 20 million cells of...
00:56 , Jan 25, 2019 |  BC Innovations  |  Product R&D

Rubius turns immunotherapy red

As it gets ready to bring the first engineered red blood cell therapy into the clinic, Rubius Therapeutics Inc. is working up the next generation of RBC therapies to mimic immune cell interactions. The company...
00:00 , Dec 12, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neurology Patient sample and mouse studies suggest depleting microglia with CSF1R inhibitors could help treat chemotherapy-induced neurological dysfunction. In postmortem frontal lobe tissue samples from pediatric and young adult patients treated with methotrexate and...
17:40 , Dec 11, 2018 |  BC Innovations  |  Translation in Brief

Diseased oligodendrocytes

A Karolinska Institute team has identified subsets of oligodendrocyte lineage cells that may trigger T cell immunity in multiple sclerosis and proposed the cells as new disease targets. The findings suggest the myelin-producing cells are...
17:33 , Sep 26, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neurology Mouse studies suggest antagonizing the muscarinic receptor CHRM1 could help treat white matter injury. In a mouse model of neonatal chronic hypoxia-induced white matter injury, CHRM1 knockout in oligodendrocyte precursor cells increased axon...
19:28 , Sep 10, 2018 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: 3-D models Patient-derived oligocortical spheroids could be used to study demyelinating diseases and screen therapies to treat them. The spheroids were generated by culturing human pluripotent stem cells with platelet derived growth factor AA...
01:46 , Aug 17, 2018 |  BC Innovations  |  Targets & Mechanisms

Unsaturated remyelination

Enzymes downstream in cholesterol biosynthesis could provide new ways to stimulate remyelination that avoid the baggage of previously identified multiple sclerosis targets, according to a group at Case Western. The university is spinning out Convelo...
23:49 , Aug 8, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neurology Mouse studies suggest CHRM3 antagonists could help treat demyelination diseases. In a mouse model of CNS demyelination, transplantation into the corpus callosum of CHRM3-deficient human oligodendrocyte progenitor cells (OPCs) increased the number of...
18:58 , May 9, 2018 |  BC Innovations  |  Translation in Brief

Dissecting rare gliomas

In an April Science study, researchers from Massachusetts General Hospital and Harvard Medical School identified a subpopulation of malignant cells driving disease progression in rare pediatric gliomas with mutated histone H3 K27M using single-cell RNA...
19:27 , Jan 4, 2018 |  BC Innovations  |  Translation in Brief

ArunA’s exosome entrance

Stem cell manufacturer ArunA Biomedical Inc. has announced a pivot into the exosome therapeutic space, as well as publication of the first data showing its neural stem cell-derived exosomes and other extracellular vesicles are effective...