BioCentury | Feb 1, 2020
Preclinical News

Cellular fluorescence assay to assess allosteric modulator potency in drug discovery

Karolinska, Pasteur and UCSD researchers have developed a cellular fluorescence assay that can efficiently screen for potent transcription factor allosteric modulators during lead identification. Unlike compounds that work by binding targets’ active sites, allosteric modulators...
BioCentury | Aug 3, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: July 2017

New Therapeutic Targets and Biomarkers: July 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during July 2017. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Jul 25, 2017
Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell culture and mouse studies suggest nanoparticles loaded with siRNAs targeting SOX2 , OLIG2 , SALL2 , and POU3F2 could help treat the proneural subtype of glioblastoma multiforme (GBM). In two proneural GBM cell lines,...
BioCentury | May 25, 2017
Emerging Company Profile

Total reprogramming

University of Cambridge spinout Elpis Biomed Ltd. has a platform that rapidly produces stockpiles of pure, mature cell types from human pluripotent stem cells. While the company is first focusing on creating well-defined disease models,...
BioCentury | May 11, 2017
Tools & Techniques

Stemming the tide

OncoMed’s bad April has all the hallmarks of a death knell for the once-promising technology of cancer stem cells, adding to the pile of preclinical breakthroughs that didn’t translate to the clinic. But many insiders...
BioCentury | Apr 18, 2017
Distillery Techniques

Disease models

TECHNOLOGY: Cell models A method for differentiating hPSCs into specific cell types by expressing select transcription factors could aid the development of cell-based disease models. The method involved engineering hPSCs via CRISPR-associated protein 9 (Cas9)-guided...
BioCentury | May 19, 2014
Emerging Company Profile

Curtana: Curtains for CSCs

...VP of Biology Gordon Alton, OLIG2 can either homodimerize or heterodimerize with the related protein OLIG1...
BioCentury | Dec 9, 2013
Company News

Curtana Pharmaceuticals, University of California deal

In September, newco Curtana received exclusive, worldwide rights to preclinical small molecule inhibitors against oligodendrocyte transcription factor 2 (OLIG2) from the university to treat glioblastoma multiforme and other cancers. Curtana plans to submit an IND...
BioCentury | May 16, 2013
Tools & Techniques

Myelination gets direct

Separate groups at the Case Western Reserve University School of Medicine and the Stanford University School of Medicine have developed similar approaches to directly reprogram rodent fibroblasts into oligodendrocyte progenitor cells. 1,2 The direct lineage...
BioCentury | May 2, 2013
Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Fibroblast-derived induced oligodendrocyte progenitor cells (iOPCs) to treat myelination disorders Two separate studies developed methods to reprogram mouse fibroblasts into iOPCs...
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