BioCentury | Oct 19, 2018
Company News

Roche culls pipeline, cuts include in-licensed, acquired programs

Roche (SIX:ROG; OTCQX:RHHBY) announced in its 3Q18 earnings it discontinued development of five new molecular entities, including Phase II rheumatoid arthritis candidate RG6125 (SDP051), plus two programs in development for follow-on indications. The pharma lost...
BioCentury | Oct 17, 2018
Company News

Roche culls pipeline, cuts include in-licensed, acquired programs

Roche (SIX:ROG; OTCQX:RHHBY) announced in its 3Q18 earnings it discontinued development of five new molecular entities, including Phase II rheumatoid arthritis candidate RG6125 (SDP051), plus two programs in development for follow-on indications. The pharma lost...
BioCentury | Oct 31, 2017
Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on 30 genomic loci could help predict the risk of schizophrenia. Genome-wide association studies in 47,559 schizophrenia patients and 70,936 healthy volunteers identified associations between the disease and SNPs on 30 loci,...
BioCentury | Oct 19, 2015
Company News

Adheron, Roche deal

Roche will acquire Adheron, a developer of technology that disrupts cell adhesion via cell surface protein cadherin 11 ( Cad-11 ; CDH11 ). Adheron is investigating therapies for inflammatory and autoimmune disorders, including rheumatoid arthritis and...
BioCentury | Oct 10, 2015
Company News

Roche to acquire Adheron

Roche (SIX:ROG; OTCQX:RHHBY) will acquire Adheron Therapeutics Inc. (Berkeley, Calif.), a developer of technology that disrupts cell adhesion via cell surface protein Cadherin 11 ( Cad-11 ; CDH11 ). Adheron is investigating therapies for inflammatory and...
BioCentury | May 28, 2015
Targets & Mechanisms

Joint attack

A newly discovered pathway that causes joint erosion in rheumatoid arthritis could lead to a new class of therapies that act locally in cells of the synovial lining and avoid the drawbacks of immunosuppressants. The...
BioCentury | Feb 10, 2014
Clinical News

SDP051: Phase I data

A placebo-controlled Phase I trial in healthy volunteers showed that single ascending-doses of SDP051 were well tolerated up to 10 mg/kg with no evidence of significant adverse events. Next year, Adheron plans to start a...
BioCentury | Apr 10, 2008
Cover Story

Metastasis, Interrupted

...Among the upregulated molecules were three that are often seen in invasive breast cancer: OB-cadherin (cadherin-11...
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