BioCentury | Sep 6, 2019
Clinical News

Opdivo misses in latest GBM readout

...trial evaluated temozolomide and radiation therapy with and without Opdivo in newly diagnosed, O6-methylguanine-DNA methyltransferase (MGMT)-methylated...
...OS benefit over SOC in the Phase III CheckMate -498 study, which evaluated Opdivo in MGMT-unmethylated...
BioCentury | Aug 2, 2019
Distillery Techniques

Genetic biomarkers for anorexia nervosa

...individuals. Four of the loci mapped to single genes: cell adhesion molecule 1 (CADM1), O6-alkylguanine alkyltransferase (MGMT...
...10 type 2 T2 (CDH10) Cell adhesion molecule 1 (CADM1) Forkhead box P1 (FOXP1) Inositol hexakisphosphate kinase-2 (IP6K2) O6-alkylguanine alkyltransferase (MGMT) Polypyrimidine...
BioCentury | May 17, 2019
Clinical News

AbbVie's antibody-drug conjugate misses mark in Phase III GBM trial

...that PD-1 inhibitor Opdivo nivolumab failed a Phase III trial for newly diagnosed O6-methylguanine-DNA methyltransferase (MGMT)-unmethylated...
BioCentury | May 9, 2019
Clinical News

May 9 Clinical Quick Takes: Polyphor, BMS, Cel-Sci, University of Pittsburgh, Merck, Scholar Rock, Promethera

...plus radiation in the Phase III CheckMate -498 trial to treat newly diagnosed O6-methylguanine-DNA methyltransferase (MGMT)-unmethylated...
BioCentury | Feb 5, 2019
Distillery Therapeutics

Cancer

...the MGMT inhibitor decreased growth compared with any agent alone. Next steps include testing undisclosed MGMT...
...Ltd. have mocetinostat in Phase II testing for hematologic malignancies and solid tumors. TARGET/MARKER/PATHWAY: O6-alkylguanine alkyltransferase (MGMT...
...email: liuzh@cicams.ac.cn Claire Quang abexinostat (PCI-24781, cra-024781) entinostat (KHK2375, SNDX-275, ms-275) mocetinostat (MGCD0103, MG-0103) Peking Union Medical College Histone deacetylase (HDAC) O6-alkylguanine alkyltransferase (MGMT) Ubiquitin...
BioCentury | Apr 27, 2018
Clinical News

DelMar reports Phase II data for VAL-083 in recurrent GBM

...Research meeting in Chicago. The open-label, U.S. trial is enrolling about 48 patients with O6-alkylguanine alkyltransferase (MGMT)-unmethylated...
...VAL-083) Business: Cancer Molecular target: DNA Description: Small molecule bifunctional alkylating agent Indication: Treat O6-alkylguanine alkyltransferase (MGMT)-unmethylated...
BioCentury | Oct 12, 2017
Emerging Company Profile

Chemo-proof T cells

...Resistant Immunotherapy (DRI) technology, the newco engineers allogeneic or autologous γδ T cells to express MGMT...
...with high dose chemo,” Ho said. Chemotherapy shrinks the tumor and kills Tregs, enabling the MGMT-expressing...
...Cantanhede, Portugal University of Alabama at Birmingham, Birmingham, Ala. Targets IL-6 - Interleukin-6 MGMT - O6-alkylguanine alkyltransferase...
BioCentury | Sep 15, 2017
Clinical News

DelMar starts Phase II of VAL-083 for MGMT-unmethylated GBM

...Pharmaceuticals Inc. (NASDAQ:DMPI) began a Phase II trial of VAL-083 to treat newly diagnosed O6-alkylguanine alkyltransferase (MGMT)-unmethylated...
...Injection) Business: Cancer Molecular target: DNA Description: Small molecule bifunctional alkylating agent Indication: Treat O6-alkylguanine alkyltransferase (MGMT)-unmethylated...
BioCentury | Jul 14, 2017
Clinical News

ImmunoCellular suspends Phase III GBM trial of ICT-107 for lack of cash

...Secondary endpoints include OS in patients with unmethylated O6-methylguanine-DNA methyltransferase (MGMT) tumors and with methylated MGMT...
...Overall survival (OS); OS in patients with unmethylated O6-methylguanine-DNA methyltransferase (MGMT) tumors and with methylated MGMT...
BioCentury | Jan 27, 2017
Clinical News

VAL-083: Ph II started

...of each 21-day cycle for up to 12 cycles in about 48 patients with O6-alkylguanine alkyltransferase (MGMT)-unmethylated...
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