BioCentury | Nov 25, 2019
Clinical News

Months after NASH failure, more woes for CymaBay's lead product on safety

...from an immunoallergic or inflammatory process. CymaBay has two remaining products: GPR119 agonist MBX-2982 and GPR120...
...I for NASH and NAFLD. Targets: GPR119 - G protein-coupled receptor 119; GPR120 (O3FAR1) - G protein-coupled receptor 120...
BioCentury | Sep 14, 2017
Strategy

Numerate’s Intelligence

...also looking for a partner to advance another one of its internal programs: agonists of GPR120...
...2 δ subunit 1 FFAR1 (GPR40) - Free fatty acid receptor 1 GPR120 (O3FAR1) - G protein-coupled receptor 120...
...intelligence” BioCentury Innovations (2017) Winnie Pong, Staff Writer Numerate Inc. Servier Takeda Pharmaceutical Co. Ltd. twoXAR Inc. University of California Los Angeles G protein-coupled receptor 120 (GPR120) (O3FAR1) Ryanodine...
BioCentury | Nov 15, 2016
Distillery Therapeutics

Endocrine / Metabolic

...INDICATION: Obesity Cell culture and mouse studies identified a non-acidic sulfonamide-based GPR120 agonist that could help...
...testing of non-acidic sulfonamide analogs in cell-based GPR120 ligand-binding assays yielded a compound that agonized GPR120...
...testing the compound in additional models of obesity, insulin resistance and diabetes. TARGET/MARKER/PATHWAY: G protein-coupled receptor 120 (GPR120; O3FAR1...
BioCentury | Nov 6, 2014
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Diabetes G protein-coupled receptor 120 (GPR120; O3FAR1) Mouse...
...mice. In insulin-resistant, obese mice, oral administration of 9-PAHSA or 5-PAHSA increased levels of active Gpr120...
BioCentury | Nov 6, 2014
Targets & Mechanisms

Greasing insulin

...be used to restore insulin sensitivity in patients with diabetes. 1 G protein-coupled receptor 120 ( GPR120 ; O3FAR1...
...GPR120. Now, a team at Harvard Medical School has identified fatty acids that operate through GPR120...
...all the biology that has been worked out for GPR120." In 2010, Olefsky's group identified GPR120...
BioCentury | Aug 14, 2014
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...information Endocrine/metabolic disease Diabetes G protein-coupled receptor 120 (GPR120; O3FAR1) Cell culture and mouse studies have identified a GPR120...
...2 diabetes. In cell culture studies, a compound was identified that had selectivity for mouse Gpr120...
...fatty acid receptor 1 (Ffar1; Gpr40) and that activated downstream signaling in human and mouse GPR120+...
BioCentury | Aug 12, 2013
Emerging Company Profile

Sensor: Combination gut shot

...the systemic production of multiple pro-inflammatory cytokines, such as G protein-coupled receptor 119 (GPR119) , GPR120...
BioCentury | Mar 8, 2012
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...and genetic studies suggest defects in GPR120 signaling increase susceptibility to obesity and obesity-related pathologies. GPR120-deficient...
...6,942 obese individuals and 7,654 control subjects of European descent, an R270H missense mutation in GPR120...
...doi:10.1038/scibx.2012.255 Published online March 8, 2012 Patent applications filed covering GPR120 agonists and activators of GPR120...
BioCentury | Mar 8, 2012
Distillery Therapeutics

Indication: Autoimmune Disease

...and genetic studies suggest defects in GPR120 signaling increase susceptibility to obesity and obesity-related pathologies. GPR120-deficient...
...6,942 obese individuals and 7,654 control subjects of European descent, an R270H missense mutation in GPR120...
...doi:10.1038/scibx.2012.255 Published online March 8, 2012 Patent applications filed covering GPR120 agonists and activators of GPR120...
BioCentury | Mar 8, 2012
Targets & Mechanisms

An obesity angle for GPR120

...another team had reignited interest in GPR120 as a diabetes target. G protein-coupled receptor 120 ( O3FAR1 ; GPR120...
...more severe glucose intolerance, insulin resistance and fatty liver than wild-type Gpr120 expression. In the Gpr120...
...genetic association studies to identify links between GPR120 and obesity. "The hypothesis was that if GPR120...
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