BioCentury | Jan 8, 2018
Distillery Techniques

Biomarkers

...affiliation as above email: Erica.golemis@fccc.edu Hongjiang Li Fox Chase Cancer Center Nuclear receptor binding SET domain protein 1 (NSD1) Nuclear SET domain-containing protein 2...
BioCentury | Dec 8, 2017
Targets & Mechanisms

Epiphenomena at ASH

...6B; MLL1 (MLL; HRX; KMT2A) - Myeloid-lymphoid or mixed-lineage leukemia protein; NSD2 (WHSC1; MMSET) - Nuclear SET domain-containing protein 2...
BioCentury | Apr 6, 2017
Distillery Therapeutics

Cancer

...steps could include identifying and testing WHSC1 inhibitors in models of metastatic prostate cancer. TARGET/MARKER/PATHWAY: Nuclear SET domain-containing protein 2...
...doi:10.1172/JCI91144 CONTACT: Jun Qin, Chinese Academy of Sciences, Shanghai, China email: qinjun@sibs.ac.cn Hongjiang Li Chinese Academy of Sciences Nuclear SET domain-containing protein 2...
BioCentury | Jul 31, 2014
Translation in Brief

Translational tidbits

...the nuclear SET domain-containing protein subfamily of HMTs as a particular goal of this effort. Nuclear SET domain-containing protein 2...
BioCentury | May 15, 2014
Cover Story

Chromatin's rising tide

...Cancer Cell Line Encyclopedia. 16 The method led the team to discover activating mutations in nuclear SET domain-containing protein 2...
BioCentury | Oct 17, 2013
Strategy

Clinical takeoff for new epigenetic targets

...a trio of HMTs: DOT1L , enhancer of zeste homolog 2 ( EZH2 ) and nuclear SET domain-containing protein 2...
BioCentury | Oct 10, 2013
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Multiple myeloma (MM) Nuclear SET domain-containing protein 2 (NSD2; MMSET...
BioCentury | Oct 10, 2013
Distillery Techniques

Technology: Assays & screens

...of a subgroup of acute lymphoblastic leukemia (ALL) cells carrying E1099K activating mutations in the nuclear SET domain-containing protein 2...
BioCentury | Oct 10, 2013
Cover Story

NSD2 momentum

...public in June and now boasts a market cap of more than $1 billion. NSD2 (nuclear SET domain-containing protein 2...
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