BC Innovations | May 20, 2019
Distillery Therapeutics

Treating obesity and metabolic syndrome via NR4A2 agonism

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Obesity; metabolic syndrome Mouse studies suggest agonizing NR4A2 could help treat obesity and obesity-associated metabolic syndrome. In a mouse model of diet-induced obesity, skeletal muscle-specific NR4A2 overexpression increased glucose tolerance and...
BioCentury | Jan 12, 2015
Emerging Company Profile

Targeting transcription regulators

The founders of Inventiva S.A.S. are using a platform from predecessor company Laboratoires Fournier S.A. to discover small molecules that target epigenetic enzymes, transcription factors and nuclear receptors for oncology, fibrosis and autoimmune disease. The...
BC Week In Review | Apr 2, 2012
Company News

Acadia Pharmaceuticals, The Michael J. Fox Foundation for Parkinson's Research neurology news

Acadia received a supplemental grant of $322,000 from the foundation to develop selective agonists of nuclear receptor subfamily 4 group A member 2 (NR4A2; NURR1) to treat Parkinson's disease. The grant was awarded to expand...
BC Innovations | Jul 28, 2011
Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Generation of induced dopaminergic (iDA) cells from skin fibroblasts A method for generating iDA cells from skin fibroblasts could provide a cell-based therapy for Parkinson's...
BC Innovations | Apr 30, 2009
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) Nuclear receptor subfamily 4 group A member 2 (NR4A2; NURR1) A study in mice suggests that agonizing...
BC Innovations | Apr 30, 2009
Targets & Mechanisms

Extinguishing neuroinflammation

U.S. and Australian teams have elucidated the pathway that leads to microglia activation, an early step in inflammatory neurodegenerative disorders. The studies suggest that dampening microglial activity early in disease could spare nearby neurons from...
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