BioCentury | Oct 12, 2017
Preclinical News

Team describes MECP2 gene therapy approach for Rett syndrome

In a paper published in Nature , researchers at the University of Edinburgh and colleagues showed that adeno-associated virus (AAV) delivery of a shortened version of the methyl CpG binding protein 2 ( MECP2 ; RTT) gene...
BioCentury | Feb 28, 2017
Distillery Therapeutics

Hepatic

...INDICATION: Liver disease Mouse studies suggest inhibiting NCOR1 could help treat neonatal hyperbilirubinemia. In a humanized...
...help treat neonatal hyperbilirubinemia. In a humanized mouse model of the disease, intestine-specific knockout of NCOR1...
...fat compared with normal expression. Next steps could include identifying and testing NCOR1 inhibitors. TARGET/MARKER/PATHWAY: Nuclear receptor corepressor 1 (NCOR1)...
BioCentury | Dec 12, 2013
Distillery Therapeutics

Indication: Hematology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Hematology Myeloproliferative disorder Retinoic acid receptor (RAR) Mouse studies suggest RAR antagonists could help treat myelofibrosis. Mice with genetic mutations in the...
BioCentury | Apr 4, 2013
Cover Story

Closer to class IIa HDAC inhibitors

...zinc to lock HDAC4 into a conformation that prevents the multiprotein complex formation of HDAC4, nuclear receptor corepressor 1 (NCOR1)...
BioCentury | Dec 1, 2011
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...PPARg) Studies in mice suggest inhibiting interactions between NCOR1 and PPARg could help treat diabetes. NCOR1...
...that interacts with PPARg and regulates genes controlling insulin sensitivity. In mice, adipocyte-specific deletion of Ncor1...
BioCentury | Nov 3, 2011
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Thyroid disease Nuclear receptor corepressor 1 (NCOR1); thyroid hormone...
...thyroid hormone receptor-b Mouse studies suggest that blocking the interaction between thyroid hormone receptor-b and NCOR1...
...treat thyroid hormone resistance. In a mouse model of thyroid hormone resistance, expression of an Ncor1...
BioCentury | Nov 3, 2011
Distillery Therapeutics

Indication: Autoimmune disease

...12, 2011; doi:10.1038/nature10502 Contact: Seung K. Kim, Stanford University, Stanford, Calif. e-mail: seungkim@stanford.edu Thyroid disease Nuclear receptor corepressor 1 (NCOR1)...
...thyroid hormone receptor-b Mouse studies suggest that blocking the interaction between thyroid hormone receptor-b and NCOR1...
...treat thyroid hormone resistance. In a mouse model of thyroid hormone resistance, expression of an Ncor1...
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