18:47 , May 30, 2018 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Psoriasis Mouse studies suggest inhibiting the NFKBIZ pathway with dimethyl itaconate could help treat psoriasis. In a mouse model of psoriasis, dimethyl itaconate decreased skin scaling, ear thickness and mRNA expression of NFKBIZ target...
08:00 , Nov 12, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor ζ (NFKBIZ; IKBζ)

Autoimmune disease Patient sample and mouse studies suggest inhibiting NFKBIZ could help treat psoriasis. NFKBIZ levels were higher in skin samples from 17 psoriasis patients than in samples from healthy controls. In two mouse models of...
07:00 , Jun 25, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Five loci associated with susceptibility to psoriasis

Biomarkers TECHNOLOGY: SNPs Genetic studies identified five new susceptibility loci for psoriasis. Genomewide association studies in 10,262 patients with psoriasis and 21,871 controls identified associations between SNPs on five loci and the disease. Three of the loci...
07:00 , Oct 14, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Infectious disease Nuclear factor of k light polypeptide gene enhancer in B...
07:00 , Aug 5, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Markers

Approach Summary Licensing status Publication and contact information Markers A six-gene signature involving Krupple-like factor 6 (KLF6; COPEB; ZF9), FBJ murine osteosarcoma viral oncogene homolog B (FOSB), nuclear factor of...