BioCentury | Jan 11, 2020
Targets & Mechanisms

Colitis-associated somatic mutations yield new colorectal cancer target

Kyoto University team identifies colitis-associated somatic mutations that are lost in colitis-associated cancer to reveal a new colorectal cancer target. A Japanese team has identified novel colorectal cancer targets by contrasting somatic mutations in cancerous...
BC Innovations | May 30, 2018
Distillery Therapeutics

Autoimmune disease

INDICATION: Psoriasis Mouse studies suggest inhibiting the NFKBIZ pathway with dimethyl itaconate could help treat psoriasis. In a mouse model of psoriasis, dimethyl itaconate decreased skin scaling, ear thickness and mRNA expression of NFKBIZ target...
BC Innovations | Nov 12, 2015
Distillery Therapeutics

Therapeutics: Nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor ζ (NFKBIZ; IKBζ)

Autoimmune disease Patient sample and mouse studies suggest inhibiting NFKBIZ could help treat psoriasis. NFKBIZ levels were higher in skin samples from 17 psoriasis patients than in samples from healthy controls. In two mouse models...
BC Innovations | Jun 25, 2015
Distillery Techniques

Techniques: Five loci associated with susceptibility to psoriasis

Biomarkers TECHNOLOGY: SNPs Genetic studies identified five new susceptibility loci for psoriasis. Genomewide association studies in 10,262 patients with psoriasis and 21,871 controls identified associations between SNPs on five loci and the disease. Three of...
BC Innovations | Oct 14, 2010
Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Infectious disease Nuclear factor of k light polypeptide gene enhancer in B cells inhibitor z (NFKBIZ; IKBZ) In vitro and...
BC Innovations | Aug 5, 2010
Distillery Techniques

Technology: Markers

Approach Summary Licensing status Publication and contact information Markers A six-gene signature involving Krupple-like factor 6 (KLF6; COPEB; ZF9), FBJ murine osteosarcoma viral oncogene homolog B (FOSB), nuclear factor of k light polypeptide gene enhancer...
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