BioCentury | Jan 11, 2020
Targets & Mechanisms

Colitis-associated somatic mutations yield new colorectal cancer target

...of cells harboring somatic mutations in inflammatory IL-17 signaling pathway components, including loss-of-function mutations in NFKBIZ...
...team verified the resulting hypothesis that NFKBIZ is required for cancer cell survival, showing that NFKBIZ...
...licensing status of the research. Targets BTRC - F-box and WD repeats protein β-TrCP NFKBIZ (IKBZ...
BioCentury | May 30, 2018
Distillery Therapeutics

Autoimmune disease

...INDICATION: Psoriasis Mouse studies suggest inhibiting the NFKBIZ pathway with dimethyl itaconate could help treat psoriasis...
...mouse model of psoriasis, dimethyl itaconate decreased skin scaling, ear thickness and mRNA expression of NFKBIZ...
...TARGET/MARKER/PATHWAY: Nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor ζ (NFKBIZ; IKBZ...
BioCentury | Nov 12, 2015
Distillery Therapeutics

Therapeutics: Nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor ζ (NFKBIZ; IKBζ)

...Autoimmune disease Patient sample and mouse studies suggest inhibiting NFKBIZ could help treat psoriasis. NFKBIZ levels...
...patients than in samples from healthy controls. In two mouse models of psoriasis-like skin inflammation, NFKBIZ...
...NFKBIZ. TARGET/MARKER/PATHWAY: Nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor ζ (NFKBIZ...
BioCentury | Jun 25, 2015
Distillery Techniques

Techniques: Five loci associated with susceptibility to psoriasis

...factor of κ light polypeptide gene enhancer in B cells inhibitor ζ ( NFKBIZ ; IKBZ...
...keratinocyte cell line, interleukin-17 (IL-17) - a cytokine involved in psoriasis - induced expression of NFKBIZ...
BioCentury | Oct 14, 2010
Distillery Therapeutics

Indication: Infectious disease

...suggest that increasing NFKBIZ expression could help boost the antiviral response. In cytokine-stimulated NK cells, NFKBIZ...
...activity than those in wild-type controls. Next steps could include testing the effects of increased NFKBIZ...
BioCentury | Aug 5, 2010
Distillery Techniques

Technology: Markers

...homolog B (FOSB), nuclear factor of k light polypeptide gene enhancer I B cells inhibitor-z (NFKBIZ...
...an analysis of gene expression profiles of tumors from patients with PDAC, six genes-KLF6, FOSB, NFKBIZ...
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